The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
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The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]
Nature CommunicationsArteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw +15 more
doaj +5 more sources
The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]
PLoS PathogensThe neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na +4 more
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Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]
Nature CommunicationsThe blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse +18 more
doaj +4 more sources
Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. [PDF]
PLoS ONE, 2017 Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and
Bence Szikora +4 more
doaj +6 more sources
Regulation of immune responses by the neonatal Fc receptor and its therapeutic implications [PDF]
Frontiers in Immunology, 2015 As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation.
Timo eRath +4 more
doaj +14 more sources
Interactions of IgG1 CH2 and CH3 domains with FcRn [PDF]
Frontiers in Immunology, 2014 Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, when compared to full-size antibodies, most of the current antibody fragments of VH or VL display greatly reduced
Tianlei eYing +4 more
doaj +3 more sources
Integrative structural insights into the IgG-FcRn interactions revealed by engineered FcRn-immobilized affinity chromatography [PDF]
Communications BiologyMolecular interactions between therapeutic antibodies and neonatal Fc receptor (FcRn) are major contributors to the long serum half-life of antibodies. Therefore, the in vitro affinity of IgG for FcRn is an important indicator of in vivo pharmacokinetic ...
Masato Kiyoshi +11 more
doaj +2 more sources
Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor [PDF]
Nature CommunicationsHuman astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz +5 more
doaj +2 more sources
Frontiers in Immunology, 2021 Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present.
Noémie Corcos +6 more
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