The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
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The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]
Nature CommunicationsArteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw +15 more
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The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]
PLoS PathogensThe neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na +4 more
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The neonatal Fc receptor in cancer FcRn in cancer
Cancer Medicine, 2020 Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda +4 more
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Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier [PDF]
Nature CommunicationsThe blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases.
Julien Lafrance-Vanasse +18 more
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Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. [PDF]
PLoS ONE, 2017 Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and
Bence Szikora +4 more
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Human Antibody Isotypes, Subclasses, Allotypes and Fc Biology: Clinical Implications in Infectious Diseases, Autoimmunity, and Cancer [PDF]
PharmaceuticalsTherapeutic antibodies have transformed the management of infectious diseases, autoimmune disorders, and cancer, yet most approved agents continue to rely on a limited range of IgG-based Fc scaffolds.
Surabhi Gautam +4 more
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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics [PDF]
MAbs, 2018 Mengmeng Wang +2 more
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Neonatal Fc Receptor (FcRn) Enhances Tissue Distribution and Prevents Excretion of nab-Paclitaxel [PDF]
Molecular Pharmaceutics, 2019 Manjunath P Pai, Miao He
exaly +2 more sources
Frontiers in Immunology, 2021 Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present.
Noémie Corcos +6 more
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