“Ways in which the neonatal Fc-receptor is involved in autoimmunity”
Journal of Translational Autoimmunity, 2021 Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved from immunoglobulin recycling and biodistribution to antigen presentation and immune complex routing, bringing it to the center of both humoral and cellular immune responses ...
Juliette Lamamy +5 more
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mAbs, 2023 The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
Jason Tien +13 more
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The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity [PDF]
, 2012 The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense.
Blumberg, Richard Steven +9 more
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Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang +8 more
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Expression of neonatal Fc receptor in the eye [PDF]
, 2014 PURPOSE: The neonatal Fc receptor (FcRn) plays a critical role in the homeostasis and degradation of immunoglobulin G (IgG). It mediates the transport of IgG across epithelial cell barriers and recycles IgG in endothelial cells back into the bloodstream.
Christianson, G. J. +4 more
core +1 more source
Frontiers in Immunology, 2015 Despite the reasonably long half-life of IgGs, market pressure for higher patient convenience while conserving efficacy continues to drive IgG half-life improvement.
Céline eMonnet +8 more
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Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]
, 2019 Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang +8 more
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Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn
Brain Research, 2013 Monoclonal antibody (mAb) engineering that optimizes binding to receptors present on brain vascular endothelial cells has enabled them to cross through the blood-brain barrier (BBB) and access the brain parenchyma to treat neurological diseases. However, once in the brain the extent to which receptor-mediated reverse transcytosis clears mAb from the ...
Cooper, Philip R. +7 more
openaire +2 more sources
Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) [PDF]
Journal of Biological Chemistry, 2006 We describe here the functional implications of an increase in IgG binding to the neonatal Fc receptor. We have defined in a systematic fashion the relationship between enhanced FcRn binding of a humanized anti-respiratory syncytial virus (RSV) monoclonal antibody (MEDI-524) and the corresponding biological consequences in cynomolgus monkeys.
William F, Dall'Acqua +2 more
openaire +2 more sources
New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]
, 2014 There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P. +2 more
core +3 more sources