Results 51 to 60 of about 5,389 (128)

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Mapping obstetric biobanks: A scoping review highlighting gaps in the study of alloimmunized pregnancies

Transfusion, EarlyView.
Abstract Background Maternal red cell alloimmunization can cause hemolytic disease of the fetus and newborn (HDFN), yet prediction of disease severity remains limited. Biobanks that link pregnancy biospecimens with clinical and laboratory data could accelerate translational research; however, the landscape of relevant obstetric biobanks has not been ...
Orlin Chowdhury, Chantal Armali, Catherine Devion, Sasha Kyser‐Burke, Akash Gupta, Noor Niyar N. Ladhani, Harley Meirovich, Hubert Tsui, Noah Zweig, Yulia Lin, Heather VanderMeulen   +10 more
wiley   +1 more source

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight
The homeostasis of IgG is maintained by the neonatal Fc receptor, FcRn. Consequently, antagonism of FcRn to reduce endogenous IgG levels is an emerging strategy for treating antibody-mediated autoimmune disorders using either FcRn-specific antibodies or ...
Guanglong Ma, Andrew R. Crowley, Liesbeth Heyndrickx, Ilse Rogiers, Eef Parthoens, Jolien Van Santbergen, Raimund J. Ober, Vladimir Bobkov, Hans de Haard, Peter Ulrichts, Erik Hofman, Els Louagie, Bianca Balbino, E. Sally Ward   +13 more
doaj   +1 more source

The conserved human astrovirus-receptor interface reveals a targetable vulnerability for antiviral development

Nature Communications
Human astrovirus (HAstV) is a major cause of viral enteritis in children and the older adults worldwide. The eight serotypes of classical HAstVs (HAstV1-8), employ the neonatal Fc receptor (FcRn) as an entry receptor.
Wei Wang, Ying Xu, Zehou Li, De Liu, Ke Ma, Rui Wang, Rong Chen, Bo Shu, Xiaoman Sun, Yue Liu, Xianliang Ke, Shuijun Zhang   +11 more
doaj   +1 more source

Long-term safety, tolerability, and efficacy of subcutaneous efgartigimod PH20 in generalized myasthenia gravis: final results from a phase 3 open-label extension study (ADAPT-SC+)

Frontiers in Neurology
BackgroundEfgartigimod is a human immunoglobulin (IgG1) antibody Fc fragment that reduces IgG levels through neonatal Fc receptor blockade. ADAPT-SC+ assessed the long-term safety, tolerability, and efficacy of subcutaneous (SC) efgartigimod PH20 in ...
Andreas Meisel, Carlo Antozzi, Ratna Bhavaraju-Sanka, Jan L. De Bleecker, Wan-Yi Huang, Rosa Hermina Jimenez, Fien M. Verhamme, Ming Jiang, Li Liu, Denis Korobko, Anna Kostera-Pruszczyk, Kimiaki Utsugisawa, Jan J. G. M. Verschuuren, Tuan Vu, Heinz Wiendl, James F. Howard   +15 more
doaj   +1 more source

Sequential and Concurrent C5 and Neonatal Fc Receptor Inhibition in Prolonged Myasthenic Crisis due to Advanced Invasive Thymoma‐Associated Myasthenia Gravis: A Case Report and Literature Review

Clinical and Experimental Neuroimmunology, Volume 17, Issue 4, November 2026.
ABSTRACT Thymoma‐associated myasthenia gravis (TAMG) is frequently refractory, particularly when complicated by myasthenic crisis in advanced invasive disease. Complement C5 inhibitors and neonatal Fc receptor (FcRn) inhibitors have expanded the treatment of acetylcholine receptor (AChR) antibody‐positive generalized myasthenia gravis; however, their ...
Yuta Kizuka, Yuriko Nakamura, Kensuke Okada, Yu Okubo, Kaoru Kaseda, Hirofumi Toyama, Keisuke Asakura, Atsuya Takeda, Jin Nakahara, Kei Ishizuchi   +9 more
wiley   +1 more source

Single‐cell atlas reveals heterogeneous response to FcRn blockade in anti‐AChR antibody‐positive generalised myasthenia gravis

Clinical and Translational Medicine
Background Myasthenia gravis (MG) is an autoimmune disease predominantly driven by autoantibodies targeting acetylcholine receptor (AChR), resulting in muscle weakness.
Hui‐Ning Li, Jingjing Liu, Xiao‐Yu Huang, Lijie Zhu, Zhirui Liu, Chun‐Sheng Yang, Bo Zhang, Shixiong Huang, Fu‐Dong Shi, Zhigang Cai, Chao Zhang   +10 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, Volume 78, Issue 10, Page 1510-1521, October 2026.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

IgG subclasses and allotypes: from structure to effector functions

Frontiers in Immunology, 2014
Of the five immunoglobulin isotypes, Immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3 and IgG4 which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains ...
Gestur eVidarsson, Gillian eDekkers, Theo eRispens   +2 more
doaj   +1 more source

Pharmacokinetics, Immunogenicity, and Safety of a Modified YTE Antibody in Healthy Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 10, October 2026.
Abstract REGN17092, a fully human immunoglobulin (Ig) G1 antibody with M252Y/S254T/T256E (YTE) modification in the Fc portion, was assessed in a first‐in‐human study (ClinicalTrials.gov, NCT05923424). REGN17092 was designed to target the severe acute respiratory coronavirus 2 (SARS‐CoV‐2) S protein.
Maria Rosario, Jan de Hoon, Flonza Isa, Kenneth Turner, Jing Li, Joel Kantrowitz, Samit Ganguly, Sasha Fraser, Zhongqing Will He, Hong Yan, Ana Gonzalez Ortiz, Lori Faria, Ingeborg Heirman, Alina Baum, Thomas D Norton, Yogesh Patel, Veronica Mas Casullo, John D Davis   +17 more
wiley   +1 more source