Results 71 to 80 of about 5,389 (128)

Targeting the neonatal Fc receptor (FcRn) to treat autoimmune diseases and maternal-fetal immune cytopenias. [PDF]

Transfusion, 2021
Wyckoff SL, Hudson KE.
europepmc   +1 more source

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

International Journal of Cell Biology, 2013
Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial ...
Guangqing Xiao, Liang-Shang Gan
doaj   +1 more source

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

Ras promotes macropinocytic nutrient uptake by suppressing the albumin recycling receptor FcRn

EMBO Reports
Macropinocytosis and lysosomal degradation of extracellular protein constitute a nutrient acquisition pathway in Ras-driven cancers. By catabolizing albumin, the most abundant plasma protein, Ras-transformed cells sustain growth in environments where ...
Rafael Paschoal de Campos, Xuxia Wu, Aslihan Inal, Zhao Liu, Craig B Thompson, Wilhelm Palm   +5 more
doaj   +1 more source

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis. [PDF]

PLoS One, 2020
Dylewski JF, Tonsawan P, Garcia G, Lewis L, Blaine J.   +4 more
europepmc   +1 more source

Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice. [PDF]

Br J Pharmacol, 2020
Kasprick A, Hofrichter M, Smith B, Ward P, Bieber K, Shock A, Ludwig RJ, Schmidt E.   +7 more
europepmc   +1 more source

Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics. [PDF]

Clin Pharmacokinet
Ternant D, Le Tilly O, Cartron G, Desvignes C, Bensalem A, Mulleman D, Bejan-Angoulvant T, Gouilleux-Gruart V, Paintaud G.   +8 more
europepmc   +1 more source

Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis. [PDF]

Immunol Res
Mausberg AK, Szepanowski F, Eggert B, Liebig KC, Kleinschnitz C, Kieseier BC, Stettner M.   +6 more
europepmc   +1 more source

Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. [PDF]

Brain Behav Immun
Fiore NT, Willcox KF, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.   +5 more
europepmc   +1 more source

The neonatal Fc receptor (FcRn) is required for porcine reproductive and respiratory syndrome virus uncoating. [PDF]

J Virol
Yang K, Dong J, Li J, Zhou R, Jia X, Sun Z, Zhang W, Li Z.   +7 more
europepmc   +1 more source