Results 81 to 90 of about 5,389 (128)

Cross-Species Extrapolation of Neonatal Fc Receptor (FcRn) Binding Affinity to Predict Monoclonal Antibody Pharmacokinetics in Humans Using Physiologically Based Pharmacokinetic Modeling (PBPK): Are We There Yet? [PDF]

ACS Pharmacol Transl Sci
Benamara S, Troisi C, Gattacceca F, Sjögren E, Nguyen L, Teutonico D.   +5 more
europepmc   +1 more source

Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. [PDF]

Am J Hematol
Jacobs JW, Booth GS, Raza S, Clark LM, Fasano RM, Gavriilaki E, Abels EA, Binns TC, Duque MA, McQuilten ZK, Mingot-Castellano ME, Savani BN, Sharma D, Tran MH, Tormey CA, Moise KJ, Bloch EM, Adkins BD.   +17 more
europepmc   +1 more source

Blocking the neonatal Fc receptor as a novel approach to prevent cardiac neonatal lupus: a proof-of-concept study. [PDF]

Ann Rheum Dis
Carlucci PM, Masson M, Cuneo BF, Brandt JS, Worthing AB, Izmirly P, Fraser N, Sachan N, Donofrio MT, Clancy R, Buyon JP.   +10 more
europepmc   +1 more source

FcRn Inhibition in Autoantibody-Mediated Autoimmune Diseases: From Broad Immunosuppression to Precision IgG Modulation. [PDF]

Mediterr J Rheumatol
Chrousos GP, Skopouli FN, Moutsopoulos HM.   +2 more
europepmc   +1 more source

Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin. [PDF]

J Biol Chem, 2017
Schmidt EGW, Hvam ML, Antunes F, Cameron J, Viuff D, Andersen B, Kristensen NN, Howard KA.   +7 more
europepmc   +1 more source

Nipocalimab Phase 3 Dose Selection for Severe Hemolytic Disease of the Fetus and Newborn. [PDF]

J Clin Pharmacol
Zhou J, Xiong Y, Lam E, Ling LE, Saeed-Khawaja S, Komatsu Y, Vermeulen A, Samtani MN, Leu JH.   +8 more
europepmc   +1 more source

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn. [PDF]

Pediatr Discov
Bhatt AH, Nimbalkar SM, Patel DV, Pujara RK.   +3 more
europepmc   +1 more source

Immune Mechanisms Underlying Neonatal Protection Following Maternal RSV Vaccination. [PDF]

Int J Mol Sci
Nikolaou AI, Giapros V, Kefala MA, Papanikolaou NG, Baltogianni M, Ladomenou F.   +5 more
europepmc   +1 more source

Systemic Inflammation as a Modulator of FcRn-dependent IgG Pharmacokinetics: Implications for Broadly Neutralising Antibody Efficacy in HIV Prevention. [PDF]

Curr HIV/AIDS Rep
Khumalo A, Pillay S, Mohan J, Mahomed S, Archary D.   +4 more
europepmc   +1 more source