Results 81 to 90 of about 8,130 (203)

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, 2020
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler   +3 more
doaj   +1 more source

A freeze substitution fixation-based gold enlarging technique for EM studies of endocytosed nanogold-labeled molecules [PDF]

, 2007
We have developed methods to locate individual ligands that can be used for electron microscopy studies of dynamic events during endocytosis and subsequent intracellular trafficking.
Bjorkman, Pamela J., Gail, Anna M., He, Wanzhong, Kivork, Christine, Machinani, Suman, McIntosh, J. Richard, Morphew, Mary K., Tesar, Devin B., Tiangco, Noreen E.   +8 more
core   +1 more source

Chimeric Antigen Receptor T‐Cells in Myasthenia Gravis: Advances, Safety Challenges, and Future Directions

Muscle &Nerve, EarlyView.
ABSTRACT This review examines the emerging application of chimeric antigen receptor (CAR) T‐cell therapy in myasthenia gravis (MG), with emphasis on safety, efficacy signals, and future therapeutic potential in treatment‐refractory disease. A comprehensive literature search was conducted across PubMed, medRxiv, bioRxiv, and Google Scholar for studies ...
Tobias Hegelmaier, Alexander Duscha, Christiane Desel, Sarah Stassen, Tim Krzemien, Ann‐Katrin Hennemann, Vaia Pappa, Aiden Haghikia   +7 more
wiley   +1 more source

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

Frontiers in Immunology, 2018
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth.
Diana Cadena Castaneda, Diana Cadena Castaneda, Christine Dhommée, Christine Dhommée, Thomas Baranek, Thomas Baranek, Emilie Dalloneau, Emilie Dalloneau, Laurie Lajoie, Laurie Lajoie, Alexandre Valayer, Alexandre Valayer, Christophe Arnoult, Christophe Arnoult, Marie-Véronique Demattéi, Marie-Véronique Demattéi, Delphine Fouquenet, Delphine Fouquenet, Christelle Parent, Christelle Parent, Nathalie Heuzé-Vourc'h, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +23 more
doaj   +1 more source

Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds [PDF]

, 2017
Therapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit ...
Abhishek Saxena, Donghui Wu, Hongyan Liu, Sachdev S. Sidhu   +3 more
core   +1 more source

Hemolytic Disease of the Fetus and Newborn: Fetal RHD Genotyping, Targeted Prophylaxis, and Prenatal Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemolytic disease of the fetus and newborn (HDFN) remains a significant concern in prenatal care primarily caused by maternal alloimmunization against fetal red blood cell antigens, most commonly the D antigen. Noninvasive fetal RHD genotyping, used as a screening tool, enables targeted antenatal prophylaxis and has been implemented in several
Emilie Thorup, Steffen Thorsen, Morten Hanefeld Dziegiel, Olav Bjørn Petersen, Frederik Banch Clausen   +4 more
wiley   +1 more source

Increased susceptibility to metabolic syndrome in adult offspring of Angiotensin type 1 receptor autoantibody-positive rats. [PDF]

, 2012
Aims: Abnormal fetal and early postnatal growth is closely associated with adult-onset metabolic syndrome (MetS). However, the underlying etiological factors remain complex. The presence of the autoantibody against the angiotensin II type 1 receptor (AT1-
Lau, Wayne Bond, Li, Xiaoyu, Liu, Huirong, Ma, Xinliang, Song, Li, Tian, Jue, Wang, Li, Yan, Li, Yan, Zi, Yang, Lihong, Yang, Xiaoli, Zhang, Suli, Zhang, Xi, Zheng, Ronghua   +13 more
core   +2 more sources

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery [PDF]

, 2013
Nanoparticles are poised to have a tremendous impact on the treatment of many diseases, but their broad application is limited because currently they can only be administered by parenteral methods.
Alexis, Frank, Blumberg, Richard S., Farokhzad, Omid C., Karnik, Rohit, Kuo, Timothy T., Langer, Robert, Levy-Nissenbaum, Etgar, Pridgen, Eric M.   +7 more
core   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source