Results 101 to 110 of about 8,130 (203)

IgG subclasses and allotypes: from structure to effector functions

Frontiers in Immunology, 2014
Of the five immunoglobulin isotypes, Immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3 and IgG4 which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains ...
Gestur eVidarsson, Gillian eDekkers, Theo eRispens   +2 more
doaj   +1 more source

Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis

Frontiers in Immunology, 2020
Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction.
Karissa L. Gable, Jeffrey T. Guptill, Jeffrey T. Guptill   +2 more
doaj   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

mAbs
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life.
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani   +10 more
doaj   +1 more source

Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics

Frontiers in Immunology, 2015
The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism.
Kine Marita Knudsen Sand, Kine Marita Knudsen Sand, Malin eBern, Malin eBern, Jeannette eNilsen, Jeannette eNilsen, Hanna Theodora eNoordzij, Hanna Theodora eNoordzij, Inger eSandlie, Inger eSandlie, Jan Terje eAndersen   +10 more
doaj   +1 more source

Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance

Frontiers in Immunology, 2020
In humans, maternal IgGs are transferred to the fetus from the second trimester of pregnancy onwards. The transplacental delivery of maternal IgG is mediated by its binding to the neonatal Fc receptor (FcRn) after endocytosis by the syncytiotrophoblast ...
Angelina Mimoun, Sandrine Delignat, Ivan Peyron, Victoria Daventure, Maxime Lecerf, Jordan D. Dimitrov, Srinivas V. Kaveri, Jagadeesh Bayry, Sébastien Lacroix-Desmazes   +8 more
doaj   +1 more source

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy. [PDF]

, 2014
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Blank, Dennis, de Haas, Masja, Deelder, André M, Einarsdottir, Helga K, Jackson, Dave, Kapur, Rick, Killie, Mette Kjaer, Koeleman, Carolien A M, Kumpel, Belinda, Kustiawan, Iwan, Michaelsen, Terje E, Porcelijn, Leendert, Rispens, Theo, Skogen, Björn, van der Schoot, C Ellen, Vestrheim, Anne, Vidarsson, Gestur, Visser, Remco, Wuhrer, Manfred   +18 more
core   +2 more sources

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport

Frontiers in Immunology, 2018
Maternal antibodies provide protection for the developing fetus. Transplacental transport of pathogenic autoantibodies might pose a risk for the developing fetus. The transport of antibodies across the placenta to the fetal circulation occurs through the
Simone Mader, Lior Brimberg, John N. Soltys, Jeffrey L. Bennett, Jeffrey L. Bennett, Betty Diamond   +5 more
doaj   +1 more source

Analysis of a compartmental model of endogenous immunoglobulin G metabolism with application to multiple myeloma [PDF]

, 2017
Immunoglobulin G (IgG) metabolism has received much attention in the literature for two reasons: (i) IgG homeostasis is regulated by the neonatal Fc receptor (FcRn), by a pH-dependent and saturable recycling process, which presents an interesting ...
Arnulf, Bertrand, Avet-Loiseau, Hervé, Chappell, Michael J., Decaux, Olivier, Dejoie, Thomas, Evans, Neil D., Fouquet, Guillemette, Guidez, Stéphanie, Harding, Stephen, Harel, Stéphanie, Hebraud, Benjamin, Javaugue, Vincent, Kendrick, Felicity, Leleu, Xavier, Moreau, Philippe, Richez, Valentine, Schraen, Susanna, Touzeau, Cyrille   +17 more
core   +2 more sources