Results 111 to 120 of about 8,130 (203)

Effects of Prepartum Supplementation and Yeast Fermentation Products on the Progesterone‐Modulated Transfer of Passive Immunity in Bos indicus Cows

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Inadequate colostrum intake increases risks of calf morbidity and mortality. This study investigated the effects of prepartum and early postpartum supplementation and yeast fermentation products on late‐pregnant Bos indicus cows, and the role of progesterone in mediating passive immunity transfer.
Latino G. S. Coimbra, Fran C. Cowley, Geoffry Fordyce, Luis F. P. Silva   +3 more
wiley   +1 more source

Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Journal of Biological Engineering
Background Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. The prolonged serum half-life of IgG antibody is governed by its pH-dependent interaction with FcRn, enabling efficient ...
Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung   +8 more
doaj   +1 more source

Immunoglobulin G Levels in Yemeni Preterm Newborns: Infant Factors Predominate

Reproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Background IgG levels in preterm infants play a crucial role in response to infection and inflammation. Infectious disease burden in the low‐income countries, such as Yemen, exacerbates the problem. The preterm infant's IgG sources are either maternal or fetal immune system.
Antar F. A. M. Al‐Badani, Jamil M. A. S. Obaid, Safana M. H. Al‐Sofi, Rahma A. S. Al‐Mansoub   +3 more
wiley   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]

, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl, Jabs, Wolfgang, Joseph, Jan Felix, Parr, Maria Kristina, Rehm, Daniel, Sandig, Volker, Winkler, Karsten   +6 more
core   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source

Fully human monoclonal antibody inhibitors of the neonatal Fc receptor (FcRn) reduce circulating IgG in nonhuman primates

Frontiers in Immunology, 2015
The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal ...
Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor   +12 more
doaj   +1 more source

Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca [PDF]

, 2015
Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection.
Burchmore, Richard J. S., Griffiths, Kate, Hou, Rong, Kennedy, Malcolm W., Loeffler, I. Kati, Wang, Hairui, Watson, David G., Zhang, Liang, Zhang, Tong, Zhang, Zhihe   +9 more
core   +1 more source

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

PROTEOMICS, Volume 26, Issue 5, Page 86-97, May 2026.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk, Katharina Kotschnew, Julia Hahn, Thomas Patschkowski, Gabriele von Fischer von Mollard   +4 more
wiley   +1 more source

A preliminary study of expression of human neonatal Fc-receptor (FcRn) in Escherichia coli

Asian Pacific Journal of Tropical Disease, 2014
Abstract Introduction Human neonatal Fc-receptor is a potential novel antibody binding protein for development of immunoassay. Previous studies had shown that this human protein has high affinity to Ig G either in vivo or in vitro. However, none of the studies had attempted exploring the utility of human FcRn in antibody immobilisation strategy.
W.K. Ng, T.S. Limz, N.S. Lai
openaire   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source