Results 91 to 100 of about 8,130 (203)

Contribution of Renal and Non‐Renal Clearance on Increased Total Clearance of Adalimumab in Glomerular Disease [PDF]

, 2013
The contribution of renal and non‐renal clearance toward targeted concentrations and/or effects of therapeutic proteins in nephrotic patients are unknown.
Akilesh, Akilesh, Aringer, Aringer, Bartelds, Brambell, Christianson, Ellis, Fervenza, Fervenza, Ghetie, Haymann, Joy, Le Berre, Lopez-Olivo, Lu, McCarthy, Ravani, Rovin, Ruggenenti, Shah, Stone, Trachtman, Weisman, Zhou   +24 more
core   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

A szarvasmarha neonatalis Fc receptor (bFcRn) által mediált IgG katabolizmus és epithelialis transzport molekuláris szintű elemzése = Studies on the bovine FcRn mediated IgG catabolism and epithelial transport at molecular level [PDF]

, 2009
A pályázat révén jelentősen bővítettük a szarvasmarha FcRn (bFcRn) szerepéről alkotott ismereteinket arról hogyan szabályozza ez a receptor az IgG homeosztázisát.
Doleschall, Márton, Frenyó, Vilmos László, Jancsik, Veronika, Kacskovics, Imre, Kis, Zsuzsanna, Mayer, Balázs   +5 more
core  

Quality, Non-clinical and Clinical Considerations for Biosimilar Monoclonal Antibody Development: EU, WHO, USA, Canada, and BRICS-TM Regulatory Guidelines [PDF]

, 2018
Objective: The aim was to critically evaluate well-established regulatory agencies mAb biosimilar guidelines for development and marketing authorization about quality, efficacy and safety and compare to BRICS-TM regulations to identify challenges ...
Anvisa, Castaneda-Hernandez, CBER, CBER, CBER, CBER, CBER, CBER, CBER, CDSCO, CFDA, Christl, Cofepris, Gautam, Lozda, MCC, Minghetti, Olech, Priori, Rushvi, Schiestl   +20 more
core   +5 more sources

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight
The homeostasis of IgG is maintained by the neonatal Fc receptor, FcRn. Consequently, antagonism of FcRn to reduce endogenous IgG levels is an emerging strategy for treating antibody-mediated autoimmune disorders using either FcRn-specific antibodies or ...
Guanglong Ma, Andrew R. Crowley, Liesbeth Heyndrickx, Ilse Rogiers, Eef Parthoens, Jolien Van Santbergen, Raimund J. Ober, Vladimir Bobkov, Hans de Haard, Peter Ulrichts, Erik Hofman, Els Louagie, Bianca Balbino, E. Sally Ward   +13 more
doaj   +1 more source

The conserved human astrovirus-receptor interface reveals a targetable vulnerability for antiviral development

Nature Communications
Human astrovirus (HAstV) is a major cause of viral enteritis in children and the older adults worldwide. The eight serotypes of classical HAstVs (HAstV1-8), employ the neonatal Fc receptor (FcRn) as an entry receptor.
Wei Wang, Ying Xu, Zehou Li, De Liu, Ke Ma, Rui Wang, Rong Chen, Bo Shu, Xiaoman Sun, Yue Liu, Xianliang Ke, Shuijun Zhang   +11 more
doaj   +1 more source

Maternal immunity enhances systemic recall immune responses upon oral immunization of piglets with F4 fimbriae [PDF]

, 2015
F4 enterotoxigenic Escherichia coli (ETEC) cause diarrhoea and mortality in piglets leading to severe economic losses. Oral immunization of piglets with F4 fimbriae induces a protective intestinal immune response evidenced by an F4-specific serum and ...
A Regnault, B Devriendt, B Heyman, Bert Devriendt, BL Dickinson, Bruno M Goddeeris, CC Czerkinsky, CD Hodgins, CMA Stirling, D Bourges, D Zaane Van, DJ Freedman, EJ Israel, Eric Cox, F Verdonck, FWR Brambell, G Saletti, J Cervenak, JM Rutter, JP Vaerman, K Rasschaert, LS Rott, Luc Peelman, M Lakew, M Quiding, M Yoshida, M Yoshida, Mario Van Poucke, RJ McGhee, Tiphanie Goetstouwers, Ut V Nguyen, Vesna Melkebeek, VT Nguyen, VU Nguyen, W Broeck Van den, W Broeck Van den, W Broeck Van den, W Broeck Van den, Wan HC, Lazarovits IA, Cruikshank WW, Kornfeld H, Center MD, Weller FP   +38 more
core   +4 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Single‐cell atlas reveals heterogeneous response to FcRn blockade in anti‐AChR antibody‐positive generalised myasthenia gravis

Clinical and Translational Medicine
Background Myasthenia gravis (MG) is an autoimmune disease predominantly driven by autoantibodies targeting acetylcholine receptor (AChR), resulting in muscle weakness.
Hui‐Ning Li, Jingjing Liu, Xiao‐Yu Huang, Lijie Zhu, Zhirui Liu, Chun‐Sheng Yang, Bo Zhang, Shixiong Huang, Fu‐Dong Shi, Zhigang Cai, Chao Zhang   +10 more
doaj   +1 more source