Results 11 to 20 of about 5,389 (128)

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +1 more source

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Frontiers in Immunology, 2022
IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc
Brittani M. Barrows, Brittani M. Barrows, Brittani M. Barrows, Shelly J. Krebs, Shelly J. Krebs, Ningbo Jian, Ningbo Jian, Michelle Zemil, Michelle Zemil, Bonnie M. Slike, Bonnie M. Slike, Vincent Dussupt, Vincent Dussupt, Ursula Tran, Ursula Tran, Letzibeth Mendez-Rivera, Letzibeth Mendez-Rivera, David Chang, David Chang, Anne Marie O’Sullivan, Anne Marie O’Sullivan, Brendan Mann, Brendan Mann, Eric Sanders-Buell, Eric Sanders-Buell, Zhanna Shubin, Zhanna Shubin, Matt Creegan, Matt Creegan, Dominic Paquin-Proulx, Dominic Paquin-Proulx, Philip Ehrenberg, Philip Ehrenberg, Agnes Laurence-Chenine, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Michael A. Eller, Guido Ferrari, Merlin Robb, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek, Lindsay Wieczorek   +47 more
doaj   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon   +25 more
doaj   +1 more source

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy [PDF]

Advanced Drug Delivery Reviews, 2015
Jonathan T Sockolosky, Francis C Szoka
exaly   +2 more sources

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

mAbs, 2021
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin.
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen   +7 more
doaj   +1 more source

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice [PDF]

MAbs, 2016
Sheldon Leung, Mengmeng Wang, Hendrik Neubert   +2 more
exaly   +2 more sources

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

Nature Communications, 2023
SARS-CoV-2 is primarily transmitted through droplets and airborne aerosols, and in order to prevent infection and reduce viral spread vaccines should elicit protective immunity in the airways.
Weizhong Li, Tao Wang, Arunraj M. Rajendrakumar, Gyanada Acharya, Zizhen Miao, Berin P. Varghese, Hailiang Yu, Bibek Dhakal, Tanya LeRoith, Athira Karunakaran, Wenbin Tuo, Xiaoping Zhu   +11 more
doaj   +1 more source

Human FcRn Tissue Expression Profile and Half-Life in PBMCs

Biomolecules, 2019
System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically ...
Yao-Yun Fan, Vahid Farrokhi, Teresa Caiazzo, Mengmeng Wang, Denise M. O’Hara, Hendrik Neubert   +5 more
doaj   +1 more source

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein

mAbs, 2021
Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation.
Takuo Suzuki, Noritaka Hashii, Minoru Tada, Akiko Ishii-Watabe   +3 more
doaj   +1 more source

Human IgE does not bind to human FcRn

Scientific Reports, 2022
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson   +6 more
doaj   +1 more source