Results 11 to 20 of about 8,130 (203)

The neonatal Fc receptor in cancer FcRn in cancer [PDF]

Cancer Medicine, 2020
Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda, Guillaume Brachet, Caroline Goupille, Lobna Ouldamer, Valérie Gouilleux‐Gruart   +4 more
doaj   +5 more sources

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. [PDF]

Adv Drug Deliv Rev, 2015
Immunoglobulin G (IgG)-based drugs are arguably the most successful class of protein therapeutics due in part to their remarkably long blood circulation. This arises from IgG interaction with the neonatal Fc receptor, FcRn. FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important ...
Sockolosky JT, Szoka FC.
europepmc   +8 more sources

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice. [PDF]

MAbs, 2016
The neonatal Fc receptor (FcRn) is a homeostatic receptor responsible for prolonging immunoglobulin G (IgG) half-life by protecting it from lysosomal degradation and recycling it to systemic circulation. Tissue-specific FcRn expression is a critical parameter in physiologically-based pharmacokinetic (PBPK) modeling for translational pharmacokinetics of
Fan YY, Avery LB, Wang M, O'Hara DM, Leung S, Neubert H.   +5 more
europepmc   +6 more sources

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn [PDF]

Seminars in Immunopathology, 2009
Careful regulation of the body's immunoglobulin-G (IgG) and albumin concentrations is necessitated by the importance of their respective functions. As such, the neonatal Fc receptor (FcRn) which, as a single receptor, is capable of regulating both of these molecules, has become an important focus of investigation.
Kristi, Baker, Shuo-Wang, Qiao, Timothy, Kuo, Kanna, Kobayashi, Masaru, Yoshida, Wayne I, Lencer, Richard S, Blumberg   +6 more
openaire   +4 more sources

FcRn-mediated antibody transport across epithelial cells revealed by electron tomography [PDF]

Nature, 2008
The neonatal Fc receptor (FcRn) transports maternal IgG across epithelial barriers, thereby providing the fetus or newborn with humoral immunity before its immune system is fully functional.
AH Huber, AM Sokac, B Granseth, BE Hull, DN Mastronarde, DN Mastronarde, EA Jones, FM Brodsky, G Danscher, JLAN Murk, JR Kremer, JR McIntosh, JS Bonifacino, KM McCarthy, KT Tokuyasu, L Altstiel, LE Greene, M Kleijmeer, M Mari, M Morphew, MS Ladinsky, MS Ladinsky, N Benlounes, NE Simister, R Fesce, R Halliday, R Rodewald, R Rodewald, R Rodewald, R Rodewald, RJ Ober, SD Conner, SL Schwartz, V Ghetie, W He, W He, W Stoorvogel   +36 more
core   +3 more sources

The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells [PDF]

PLoS Pathogens, 2013
The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody.
Anderson, Deborah J, Becerra, Juan C, Burton, Dennis R, Corti, Davide, Desrosiers, Ronald C, Forthal, Donald N, Gach, Johannes S, Gupta, Sandeep, Hel, Zdenek, Joseph, Sarah B, Landucci, Gary, Lanzavecchia, Antonio, Mestecky, Jiri, Moldoveanu, Zina, Moldt, Brian, Phan, Tran B, Ping, Li-Hua, Pudney, Jeffrey, Ruprecht, Ruth M, Supnet, Medalyn Jude   +19 more
core   +12 more sources

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn [PDF]

Proceedings of the National Academy of Sciences, 2008
The neonatal Fc receptor FcRn provides IgG molecules with their characteristically long half-livesin vivoby protecting them from intracellular catabolism and then returning them to the extracellular space. Other investigators have demonstrated that mice lacking FcRn are protected from induction of various autoimmune diseases, presumably because of the ...
Mezo, Adam R., McDonnell, Kevin A., Hehir, Cristina A. Tan, Low, Susan C., Palombella, Vito J., Stattel, James Michael Walker, Kamphaus, George D., Fraley, Cara, Zhang, Yixia, Dumont, Jennifer A., Bitonti, Alan J.   +10 more
openaire   +5 more sources

Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. [PDF]

Brain Behav Immun
Preclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of pronociceptive IgG, which accumulates around the lumbar region, including within the dorsal root ganglia
Fiore NT, Willcox KF, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.   +5 more
europepmc   +3 more sources

Treatment with anti-neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice. [PDF]

Br J Pharmacol, 2020
Background and PurposePemphigus and pemphigoid diseases are characterized and caused predominantly by IgG autoantibodies targeting structural proteins of the skin. Their current treatment relies on general and prolonged immunosuppression that causes severe adverse events, including death.
Kasprick A, Hofrichter M, Smith B, Ward P, Bieber K, Shock A, Ludwig RJ, Schmidt E.   +7 more
europepmc   +4 more sources

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Frontiers in Immunology, 2022
IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc
Brittani M. Barrows, Brittani M. Barrows, Brittani M. Barrows, Shelly J. Krebs, Shelly J. Krebs, Ningbo Jian, Ningbo Jian, Michelle Zemil, Michelle Zemil, Bonnie M. Slike, Bonnie M. Slike, Vincent Dussupt, Vincent Dussupt, Ursula Tran, Ursula Tran, Letzibeth Mendez-Rivera, Letzibeth Mendez-Rivera, David Chang, David Chang, Anne Marie O’Sullivan, Anne Marie O’Sullivan, Brendan Mann, Brendan Mann, Eric Sanders-Buell, Eric Sanders-Buell, Zhanna Shubin, Zhanna Shubin, Matt Creegan, Matt Creegan, Dominic Paquin-Proulx, Dominic Paquin-Proulx, Philip Ehrenberg, Philip Ehrenberg, Agnes Laurence-Chenine, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Michael A. Eller, Guido Ferrari, Merlin Robb, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek, Lindsay Wieczorek   +47 more
doaj   +1 more source