Results 51 to 60 of about 990,352 (302)
The Ligands for Human IgG and Their Effector Functions
Antibodies, 2019 Activation of the humoral immune system is initiated when antibodies recognize an antigen and trigger effector functions through the interaction with Fc engaging molecules.
Steven W. de Taeye +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Characterization of the IgG-Fc receptor on human platelets [PDF]
Blood, 1982 To determine quantitatively the number and avidity of receptors for the Fc portion of IgG on human platelets, we have measured the binding to platelets of human monomeric monoclonal IgG, and of small covalently crosslinked polymers of IgG1 labeled with 125I. The binding of labeled IgG1 monomers to platelets is too weak to permit quantitation.
S P, Karas, W F, Rosse, R J, Kurlander
openaire +3 more sources
Advanced Science, 2019 Nanocarriers for medical applications must work reliably within organisms, independent of the individual differences in the blood proteome. Variation in the blood proteome, such as immunoglobulin levels, is a result of environmental, nutrition, and ...
Domenik Prozeller +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Quantification of Receptor Targeting Aptamer Binding Characteristics Using Single-Molecule Spectroscopy [PDF]
, 2011 This experimental design presents a single molecule approach based on fluorescence correlation spectroscopy (FCS) for the quantification of outer membrane proteins which are receptors to an aptamer specifically designed to target the surface receptors of
Brittany Book +5 more
core +1 more source
Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice
Frontiers in Cell and Developmental Biology, 2020 Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases.
Olga O. Zaytseva +6 more
doaj +1 more source
Physiological and Pathological Inflammation Induced by Antibodies and Pentraxins
Cells, 2021 Macrophages play a key role in induction of inflammatory responses. These inflammatory responses are mostly considered to be instigated by activation of pattern recognition receptors (PRRs) or cytokine receptors.
Chiara Elisabeth Geyer +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2018 Supplemental material, Supplemental Table1 for Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders by Susanna Asseyer, Felix Schmidt, Claudia Chien, Michael Scheel, Klemens Ruprecht, Judith Bellmann-Strobl, Alexander U ...
Judith Bellmann-Strobl (96062) +7 more
core +1 more source