Results 51 to 60 of about 296,832 (268)
Nature CommunicationsIgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as IgG without Fc glycans cannot bind to Fcɣ receptors ...
Theresa Kissel +8 more
doaj +1 more source
Expression, Role, and Regulation of Neutrophil Fcγ Receptors
Frontiers in Immunology, 2019 Neutrophils are best known for their critical role in host defense, for which they utilize multiple innate immune mechanisms, including microbe-associated pattern recognition, phagocytosis, production of reactive oxygen species, and the release of potent
Yu Wang, Yu Wang, Friederike Jönsson
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
IgG Glyco-Engineering to Improve IVIg Potency
Frontiers in Immunology, 2018 Intravenous immunoglobulins (IVIg) are used in the treatment of different autoimmune and inflammatory diseases, such as immune thrombocytopenia and hemolytic anemia.
Christine W. Bruggeman +8 more
doaj +1 more source
How to select IgG subclasses in developing anti-tumor therapeutic antibodies
Journal of Hematology & Oncology, 2020 The intact antibody of human immunoglobulin (IgG) is composed of the fragment for antigen binding (Fab) and the crystallizable fragment (Fc) for binding of Fcγ receptors.
Jifeng Yu, Yongping Song, Wenzhi Tian
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Tissue-specific expression of IgG receptors by human macrophages ex vivo.
PLoS ONE, 2019 Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only from peripheral blood monocytes, and maintain themselves by self-renewal.
Christine W Bruggeman +10 more
doaj +1 more source
THE INDIVIDUAL DIFFERENCE OF ABILITY BINDING BRAIN TUMOR CELLS WITH IMMUNOGLOBULIN G
Медицинская иммунология, 2014 . Were researched IgG on the surface cells of different histological types tumors of cerebrum, using fluorescing staphylococcus A-protein. The study of target IgG shows divers intensive of microscopic fluorescent illumination.
O. V. Ostreiko +4 more
doaj +1 more source
The IgG Receptor Induced by Herpes Simplex Virus: studies using Radioiodinated IgG
Journal of General Virology, 1974 Summary Further evidence is presented that the receptor induced on the surface of cells infected with herpes simplex virus is specific for the Fc fragment of the IgG molecule of several species. A method has been developed for quantitative studies of this receptor using rabbit IgG labelled with [125I].
D, Westmoreland, J F, Watkins
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source