Results 61 to 70 of about 990,352 (302)

Impaired metal perception and regulation of associated human foliate papillae tongue transcriptome in long-COVID-19

Scientific Reports
Chemosensory impairment is an outstanding symptom of SARS-CoV-2 infections. We hypothesized that measured sensory impairments are accompanied by transcriptomic changes in the foliate papillae area of the tongue.
Barbara Danzer, Mateo Jukic, Andreas Dunkel, Gaby Andersen, Barbara Lieder, Erika Schaudy, Sarah Stadlmayr, Jory Lietard, Timm Michel, Dietmar Krautwurst, Bernhard Haller, Percy Knolle, Mark Somoza, Paul Lingor, Veronika Somoza   +14 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Newcombe, J, Kalina, P, Kepplinger, B, Baran, H, Ferraz-Leite, H, Kainz, A   +5 more
core  

Antilaminin IgG binds and interacts with cardiac cholinergic receptors

, 1990
Antilaminin IgG bound to cholinergic muscarinic receptors of normal mice heart and simulated the biological effect of a cholinergic agonist. Antilaminin IgG interfered with the binding of the radiolabelled muscarinic antagonist, (−)-[3H]quinuclidinyl ...
Livia Lustig, Leonor Sterin-Borda, Enri Borda, Sandra Bacman, Berta Denduchis   +4 more
core   +1 more source

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors

Cell Reports, 2015
Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody ...
Daniela Kao, Heike Danzer, Mattias Collin, Andrea Groß, Jutta Eichler, Jerko Stambuk, Gordan Lauc, Anja Lux, Falk Nimmerjahn   +8 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Properties and action mechanisms of intravenous gammaglobulin

Medicina, 2014
Intravenous immunoglobulins (IVIG) preparations have been used as a substitutive therapy for primary and secondary immunodeficiencies for many years; now it is well know that IVIG can have two other important and opposite functions: pro and anti ...
Núria Matamoros Flori
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Supplemental Table2 - Supplemental material for Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders

, 2018
Supplemental material, Supplemental Table2 for Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders by Susanna Asseyer, Felix Schmidt, Claudia Chien, Michael Scheel, Klemens Ruprecht, Judith Bellmann-Strobl, Alexander U ...
Judith Bellmann-Strobl (96062), Michael Scheel (445740), Alexander U Brandt (5705579), Felix Schmidt (312801), Friedemann Paul (25657), Susanna Asseyer (5705573), Claudia Chien (5705576), Klemens Ruprecht (187598)   +7 more
core   +1 more source

The Immunologic Functions of the Neonatal Fc Receptor for IgG [PDF]

Journal of Clinical Immunology, 2012
Careful regulation of the body's immunoglobulin G (IgG) and albumin concentrations is necessitated by the importance of their respective functions. As such, the neonatal Fc receptor (FcRn), as a single receptor, is capable of regulating both of these molecules and has become an important focus of investigation. In addition to these essential protection
Rath, Timo, Kuo, Timothy T, Baker, Kristi, Qiao, Shuo-Wang, Kobayashi, Kanna, Yoshida, Masaru, Roopenian, Derry C, Fiebiger, Edda, Lencer, Wayne I, Blumberg, Richard S   +9 more
openaire   +2 more sources