Gene Deficiency in Activating Fcγ Receptors Influences the Macrophage Phenotypic Balance and Reduces Atherosclerosis in Mice. [PDF]
PLoS ONE, 2013 Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients.
Beñat Mallavia +8 more
doaj +8 more sources
Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc [PDF]
Frontiers in Immunology, 2023 IntroductionT cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses.
Osman Dadas +10 more
doaj +2 more sources
Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis [PDF]
Cells, 2022 In phagocytes, cytoskeletal and membrane remodeling is finely regulated at the phagocytic cup. Various smaFll G proteins, including those of the Arf family, control these dynamic processes.
François C. Chouinard +3 more
doaj +2 more sources
Fcγ Receptor IIa (FCGR2A) Polymorphism Is Associated With Severe Respiratory Syncytial Virus Disease in Argentinian Infants [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 BackgroundMost patients with respiratory syncytial virus (RSV) infection requiring hospitalization have no risk factors for severe disease. Genetic variation in the receptor for the Fc portion of IgG (FcγR) determines their affinity for IgG subclasses ...
María Pía Holgado +8 more
doaj +2 more sources
Monocyte TREM-1 Levels Associate With Anti-TNF Responsiveness in IBD Through Autophagy and Fcγ-Receptor Signaling Pathways [PDF]
Frontiers in Immunology, 2021 The expression of Triggering Receptor Expressed on Myeloid cells (TREM)-1 has been described as a predictive marker for anti-Tumor Necrosis Factor (TNF)-α monoclonal antibody (mAb) therapy responsiveness in patients with inflammatory bowel disease (IBD).
Marileen M. Prins +9 more
doaj +2 more sources
Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites [PDF]
Nature Communications, 2021 Antibodies plays critical roles in the adaptive immune response to infectious agents including malaria. Here the authors defined antibody interactions with -Fcγ-receptors expressed on immune cells with sporozoites of Plasmodium falciparum, and identified
Gaoqian Feng +17 more
doaj +2 more sources
Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development [PDF]
Clinical and Translational Medicine, 2021 Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity.
Laura Lopez‐Sanz +9 more
doaj +2 more sources
Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes [PDF]
Frontiers in Immunology, 2021 The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an engineered tri-valent arrangement of IgG1 Fc domains (SIF1) potently inhibited FcγR activation
Elizabeth M. Bailey +10 more
doaj +2 more sources
Fcγ receptor–mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies [PDF]
JCI Insight, 2022 New strategies that augment T cell responses are required to broaden the therapeutic arsenal against cancer. CD96, TIGIT, and CD226 are receptors that bind to a communal ligand, CD155, and transduce either inhibitory or activating signals.
Anne Rogel +8 more
doaj +2 more sources
CLEC5a-directed bispecific antibody for effective cellular phagocytosis
mAbs, 2022 While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB).
Vivekananda Kedage +11 more
doaj +1 more source