Results 11 to 20 of about 1,252,619 (143)

Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions. [PDF]

Sci Rep, 2017
Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammatory ...
Qureshi OS, Rowley TF, Junker F, Peters SJ, Crilly S, Compson J, Eddleston A, Björkelund H, Greenslade K, Parkinson M, Davies NL, Griffin R, Pither TL, Cain K, Christodoulou L, Staelens L, Ward E, Tibbitts J, Kiessling A, Smith B, Brennan FR, Malmqvist M, Fallah-Arani F, Humphreys DP.   +23 more
europepmc   +2 more sources

Positive and negative regulation of the Fcγ receptor-stimulating activity of RNA-containing immune complexes by RNase. [PDF]

JCI Insight, 2023
Naito R., Ohmura K., Higuchi S., et al. Positive and negative regulation of the Fcγ receptor–stimulating activity of RNA-containing immune complexes by RNase. JCI Insight 8, e167799 (2023); https://doi.org/10.1172/jci.insight.167799.The U1RNP complex, Ro/
Naito R, Ohmura K, Higuchi S, Nakai W, Kohyama M, Mimori T, Morinobu A, Arase H.   +7 more
europepmc   +2 more sources

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG. [PDF]

MAbs, 2023
Antibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in ...
Crowley AR, Mehlenbacher MR, Sajadi MM, DeVico AL, Lewis GK, Ackerman ME.   +5 more
europepmc   +2 more sources

Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B [PDF]

, 2005
The Fcγ receptors play important roles in the initiation and regulation of many immunological and inflammatory processes, and genetic variants (FCGR) have been associated with numerous autoimmune and infectious diseases. The data in rheumatoid arthritis (
Barrett , Jennifer H., Griffiths, B., Old, R.W., Boylston, Arthur W., Frederique Ponchel, Morgan, Ann W., Ali, Manir, Subramanian, Deepak, Ponchel, Frederique, Ann W Morgan, Jim I Robinson, Elizabeth A Jones, R Deva Situnayake, Boylston, A.W., Arthur W Boylston, Keyte, V.H., Isaacs, John D., Alexander F Markham, Manir Ali, Morgan, A.W., Robinson, J.I., Emery, P., Griffiths, Bridget, Barrett, J.H., John D Isaacs, Subramanian, D., Old, R. W., Ponchel, F., Deepak Subramanian, Jones, E. A. (Elizabeth A.), Paul Emery, Markham, Alexander F, Keyte, Viki H., Ali, M., Markham, A.F., Deva Situnayake, R, Bridget Griffiths, Jones, E.A., Viki H Keyte, Situnayake, R.D., Robert W Old, Jennifer H Barrett, Isaacs, J.D., Robinson, Jim I., Emery, Paul   +44 more
core   +1 more source

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression [PDF]

, 2010
Background A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic ...
Hart Simon P, Wallace, William A., McFarlane, Pauline, Bournazos, Stylianos, Bournazos Stylianos, Alexander, Karen M, Karen M Alexander, Jacob Grinfeld, William A Wallace, Simpson A John, Hirani, Nikhil, McFarlane Pauline, Pauline McFarlane, Grinfeld Jacob, Grinfeld, Jacob, Hirani Nikhil, Simpson, A John, John T Murchison, Nikhil Hirani, Wallace William A, Hart, Simon P, Simpson, A. John, Dransfield, Ian, Stylianos Bournazos, Murchison John T, Alexander Karen M, Murchison, John T, Wallace, William, Ian Dransfield, Dransfield Ian, A John Simpson, Simon P Hart   +31 more
core   +2 more sources

Studies on the regulatory mechanisms of Fcγ receptor function [PDF]

, 2010
Receptors for immunoglobulins (Fc receptors) play a central role during an immune response, as they mediate the specific recognition of antigens of almost infinite diversity by leukocytes, thereby linking the innate with the adaptive branches of immunity.
Bournazos, Stylianos
core   +3 more sources

Fcγ receptor-mediated inflammation inhibits axon regeneration. [PDF]

, 2014
Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy.
Gang Zhang, Mark S Cragg, Julia J Song, Martin J Glennie, Kazim A Sheikh, Nataliia Bogdanova, Tong Gao   +6 more
core   +1 more source

Genetic polymorphism studies in periodontitis and Fcγ receptors [PDF]

, 2011
Periodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology.
L. Chai, Chai,L., Song,Y. -Q., Leung.W. K., Leung, WK, W. K. Leung, Chai, L, Song, YQ, Y.-Q. Song   +8 more
core   +1 more source

Cloning and sequence of the cDNA coding for rat type II Fcγ receptor of mast cells [PDF]

, 1993
A clone encoding the rat type II Fcγ receptor was isolated from a cDNA library of the rat mucosal mast cell line RBL-2H3 and its sequence determined. The predicted amino acid sequence is highly homologous with the mouse type II as well as rat type III ...
Pecht, Israel, Israel Pecht, Boček, Petr, Petr Boček   +3 more
core   +1 more source

Fcγ receptor signaling in response to soluble versus immobilized IgG

, 2009
Fcγ receptors present on monocytes and macrophages clear pathogens engaged by antibodies through the process of endocytosis. Upon being clustered by immune complexes, Fcγ receptors initiate signaling that lead to cellular activation and cytokine ...
Gupta, Sandeep
core   +2 more sources