Results 11 to 20 of about 24,384 (198)
Harnessing MerTK agonism for targeted therapeutics
mAbs, 2020 Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies.
Vivekananda Kedage +6 more
doaj +1 more source
Copy number variation of Fc gamma receptor genes in HIV-infected and HIV-tuberculosis co-infected individuals in sub-Saharan Africa. [PDF]
PLoS ONE, 2013 AIDS, caused by the retrovirus HIV, remains the largest cause of morbidity in sub-Saharan Africa yet almost all genetic studies have focused on cohorts from Western countries.
Lee R Machado +14 more
doaj +1 more source
Comparison of the kinetics of maturation of phagosomes containing apoptotic cells and IgG-opsonized particles. [PDF]
PLoS ONE, 2012 Defective clearance of apoptotic cells has emerged as an important contributing factor to the pathogenesis of many diseases. Although many efforts have been made to understand the machinery involved in the recognition between phagocytes and potential ...
Michelle S Viegas +2 more
doaj +1 more source
Fcγ receptor-mediated inflammation inhibits axon regeneration. [PDF]
PLoS ONE, 2014 Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy.
Gang Zhang +6 more
doaj +1 more source
Scientific Reports, 2021 Following bacterial infection, macrophages produce pro-inflammatory cytokines in response to bacterial cell components, including lipopolysaccharide (LPS) and lipopeptide, and simultaneously phagocytize and digest the invading bacteria.
Takayuki Ueno +2 more
doaj +1 more source
BMC Research Notes, 2021 Objective Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors in susceptibility to SLE.
Mansoor Karimifar +5 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Daniel L. Seiler +13 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background and aims: C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI).
Hai-Yun Li +9 more
doaj +1 more source
New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]
, 2014 There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P. +2 more
core +3 more sources
Unraveling the Role of Allo-Antibodies and Transplant Injury. [PDF]
, 2016 Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both ...
Matsuda, Yoshiko, Sarwal, Minnie M
core +5 more sources