Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice [PDF]
, 2013 Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients.
Ortiz-Muñoz, Guadalupe +30 more
core +2 more sources
Protein kinase C controls Fcγ receptor-mediated endocytosis in human neutrophils [PDF]
, 1990 The aim of this study is to clarify which signaling mechanism operates in Fcγ receptor-mediated endocytosis in human neutrophils. Endocytosis of immune complexes was inhibited by antibodies directed to cell membrane phospholipase C (PLC) and A2 (PLA2 ...
Moraru, I.I. +4 more
core +1 more source
The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands. [PDF]
, 2015 The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the most abundant subclass, has a half-life as long as that of IgG2 and IgG4,
Jayesh Gor +11 more
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Characterization of Monoclonal Antibodies, TAG1,TAG2 and TAG3 for Neutrophil Fcγ receptor IIIb [PDF]
, 2006 免疫機序による好中球減少症において, 好中球Fcγ receptor IIIb(Fcγ RIIIb)上の抗原であるNA系抗原やFcγ RIIIを標的とする抗体がしばしば検出される。抗体検出に用いられるパネル好中球と患者好中球のNA系抗原の表現型の同定にはモノクローナル抗体(mAb)または血清抗体が用いられてきた。このたび, NA1抗原認識mAb, TAG1,NA2抗原認識mAb, TAG2,Fcγ RIII認識mAb, TAG3の3つのmAbを作製した。TAG1,TAG2 ...
Taniguchi, Kikuyo
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, 1995 The contribution of mannose receptors on the cell surface of mouse peritoneal macrophages to the pro cess of liposome-induced phagocytosis of immunoglobu lin G-opsonized sheep red blood cells (SRBCs) through Fcγ receptor has been investigated.
Yukihiko Aramaki +2 more
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An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells [PDF]
, 2011 SummaryAntibodies to cell-surface antigens trigger activatory Fcγ receptor (FcγR)-mediated retrograde signals in leukocytes to control immune effector functions.
Vernes, Jean-Michel +39 more
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Influence of Fcγ receptor distribution on mannose receptor mediated phagocytosis [PDF]
, 2010 In this study the recognition maps obtained by the simultaneous topography and recognition (TREC) imaging revealed that Fcγ receptors are distributed in micro-domains of sizes 4nm to 200nm.
Ahmad, Syed Furquan (gnd: 143082981)
core +1 more source
, 2011 Rationale: Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through
Chieko Mineo +8 more
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Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor [PDF]
, 1994 We report that activation of phospholipase C (PLC) by cross-linking of the platelet low-affinity Fcγ receptor II (Fcγ RII) is inhibited by two structurally distinct tyrosine kinase inhibitors, staurosporine and ST271.
Judith Asselin +7 more
core +1 more source
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source