Results 31 to 40 of about 1,252,619 (143)

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L [PDF]

, 2014
Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of.
Cato, L., Neeb, A., Brown, Myles, Cato, Andrew C. B., Cato, A. C. B., Neeb, Antje, Brown, M., Cato, Laura   +7 more
core   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Failed Mucosal Allostasis Distinguishes Murine IgG‐ From IgE‐Mediated Recurrent Severe Anaphylaxis

Allergy, EarlyView.
This study investigates IgE‐ and IgG‐mediated pathways in acute and recurrent anaphylaxis using a murine ASA‐PSA model, assessing barrier integrity, immune activation and tissue remodelling across pulmonary and intestinal compartments. Recurrent IgE‐ and IgG‐mediated anaphylaxis produces divergent mucosal outcomes despite comparable systemic severity ...
Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Sude Toprakkaz, Mehmet Emre Topcu, Musa Ozgur Ozyigit, Ahmet Akkoc, Dane Ediger, Ferah Budak Sener   +8 more
wiley   +1 more source

A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis [PDF]

, 2014
BackgroundFcγ receptors mediate important biological signals in myeloid cells including the ingestion of microorganisms through a process of phagocytosis.
Durden, Donald L, Donald L Durden, Singh, Alok Ranjan, Shweta Joshi, Muamera Zulcic, Zulcic, Muamera, Alok Ranjan Singh, Joshi, Shweta, Alok Singh   +8 more
core   +1 more source

Spatial organization of immune receptors regulate immune cell activation: Insights from reconstituted T cell receptor and Fcγ-receptor systems [PDF]

, 2021
As immune cells patrol our body, contacting and surveying the cells around them, they must constantly make the decision of whether or not to activate and surmount an immune response.
Kern, Nadja
core   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

The yin and yang of Fcγ receptors in ITP [PDF]

, 2008
The Fcγ receptors contribute to the susceptibility to autoimmune diseases such as ITP in several ways: (1) they modulate dendritic cell antigen processing and presentation, (2) they modulate antibody production by B cells, and (3) they participate in ...
McKenzie, Steven E.
core   +1 more source

Birth‐Related Experiences and Postpartum Depression: The Protective Role of Self‐Compassion

Birth, EarlyView.
Does self‐compassion (SC) moderate the relationship between birth satisfaction, type of birth, and early skin‐to‐skin contact (SSC) in women's PPD symptoms? Methods: 987 women with an infant aged 0–5 months. 62.1% Vaginal delivery. 66.3% SSC contact after delivery.
Helena Moreira, Colin R. Martin
wiley   +1 more source

Family‐Led Decision‐Making Meetings as an Alternative to Initial Child Protection Conferences: Findings From a Realist Evaluation of the Safeguarding Family Group Conferencing Pilot in England

Child &Family Social Work, EarlyView.
ABSTRACT Safeguarding Family Group Conferencing (FGC) is a family‐led decision‐making process offered to some families in England as an alternative to an Initial Child Protection Conference when Children's Services have safeguarding concerns. A realist evaluation was conducted within three local authorities piloting this approach to build understanding
Bekkah Bernheim, Jennie Hayes, Alankrita Singh, Katrina Wyatt, Donald Forrester, Lorna Stabler   +5 more
wiley   +1 more source