Results 51 to 60 of about 24,384 (198)

FcγR Genetic Variation and HIV-1 Vaccine Efficacy: Context And Considerations

Frontiers in Immunology, 2021
Receptors for the crystallisable fragment (Fc) of immunoglobulin (Ig) G, Fcγ receptors (FcγRs), link the humoral and cellular arms of the immune response, providing a diverse armamentarium of antimicrobial effector functions.
Ria Lassaunière, Caroline T. Tiemessen, Caroline T. Tiemessen   +2 more
doaj   +1 more source

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors

Cell Reports, 2015
Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody ...
Daniela Kao, Heike Danzer, Mattias Collin, Andrea Groß, Jutta Eichler, Jerko Stambuk, Gordan Lauc, Anja Lux, Falk Nimmerjahn   +8 more
doaj   +1 more source

Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model. [PDF]

, 2018
Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are not currently
A Balmaseda, AC Brault, C Dreyfus, CH Tan, CJ Henry Dunand, David J. DiLillo, DF Robbiani, DH Barouch, DJ DiLillo, EA Henchal, F Krauer, Gopal Sapparapu, H Zhao, IY Ho, J Duehr, J Mlakar, JJ Schlesinger, JJ Schlesinger, JJ Schlesinger, JJ Schlesinger, K Smith, K Stettler, KA Dowd, KM Chung, KM Chung, L Priyamvada, Lavinia Schuler-Faccini, LR Petersen, M Hezareh, M Rastogi, NM Ferguson, O Vafa, P Avirutnan, PA Cane, PR Beatty, Q Wang, S Cauchemez, SB Halstead, Shashank Tripathi, SM Costa, SS Whitehead, Susan L. Hills, SV Bardina, SW Wan, T Schlothauer, VD Krishna, VM Cao-Lormeau, W He, WY Tsai, X Gao, X Liu, Ya-Ting Chu   +51 more
core   +3 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

A functional variant of Fcγ receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies [PDF]

, 2005
Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/B×N mice, although some groups have reported that few healthy humans retain these antibodies.
Goto Daisuke, Hayashi Taichi, Ito Satoshi, Kori Yuko, Matsumoto Isao, Muraki Yoshifumi, Sumida Takayuki, Tsutsumi Akito, Yasukochi Takanori, Zhang Hua, 伊藤 聡, 住田 孝之, 後藤 大輔, 松本 功, 林 太智   +14 more
core   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study

Arthritis Research & Therapy
Objective The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies.
Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt   +9 more
doaj   +1 more source

Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA

Frontiers in Immunology, 2023
Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody activities are mediated by both their Fab and the Fc.
Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel   +5 more
doaj   +1 more source