Results 41 to 50 of about 1,252,619 (143)

TNFR2-specific antibody fusion proteins with Fcγ receptor-independent agonism

Der TNFR2 gewinnt als therapeutisches Ziel zunehmend an Relevanz, da er bei einer Vielzahl von Erkrankungen, darunter bei Autoimmun- und Tumorerkrankungen, eine wichtige Rolle spielt.
Päckert, Lea
core   +1 more source

Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo

, 2011
Maintenance of immunological tolerance is crucial to prevent development of autoimmune disease. The production of autoantibodies is a hallmark of many autoimmune diseases and studies in mouse model systems suggest that inhibitory signaling molecules may ...
Anja Lux, Diana Dudziak, Evelyn Ullrich, Anne Baerenwaldt, Gordon Heidkamp, Falk Nimmerjahn, Bernd M. Spriewald, Heike Danzer   +7 more
core   +1 more source

Crack Process Investigation in Gears Under Single Tooth Bending Fatigue Condition Using Infrared Thermography and 3D XFEM Numerical Models

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT The present study proposes a combined approach of infrared thermography and 3D XFEM numerical models for crack process investigation in mechanical components such as gears. Over the years, fatigue crack analysis based on energy dissipations in the form of heat generated during fatigue tests has been widely reported, although mainly limited to ...
Luca Corsaro, Lorenzo Fraccaroli, Francesca Maria Curà, Franco Concli   +3 more
wiley   +1 more source

Serum Agalactosyl IgG Predicts Hepatocellular Carcinoma and All‐Cause Mortality After SVR in Advanced Chronic Hepatitis C

Hepatology Research, EarlyView.
ABSTRACT Background and Aims Patients with chronic hepatitis C and advanced fibrosis remain at substantial risk of hepatocellular carcinoma (HCC) and non‐liver–related death even after sustained virological response (SVR) to direct‐acting antivirals (DAA).
Daisuke Sakon, Jumpei Kondo, Yuki Tahata, Hayato Hikita, Maki Iwaisako, Muya Matsumoto, Asuka Ogata, Shinji Takamatsu, Yasutoshi Nozaki, Naruyasu Kakita, Hisashi Ishida, Fumihiko Nakanishi, Yuichi Yoshida, Masanori Nakahara, Kazuho Imanaka, Mitsuru Sakakibara, Takayuki Yakushijin, Tetsuo Takehara, Takahiro Kodama, Eiji Miyoshi   +19 more
wiley   +1 more source

NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]

, 2014
There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L., James P. Fuller, Jeffrey B. Stavenhagen, Jessica L. Teeling, Stavenhagen, Jeffrey B., Fuller, James P.   +5 more
core   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling

Fc receptors mediate antibody effector functions. Immunoglobulin G (IgG), the predominant antibody in circulation and in clinical use, engages diverse Fc gamma (Fcγ) receptors differentially expressed across cell types.
Schuijs, Martijn J., Van Damme, Karel F.A., De Bleser, Pieter, Van Damme, Karel, Quintelier, Katrien, Sichien, Dorine, Benigni, Fabio, Thiam, Kader, Balbino, Bianca, Pires da Silva Baptista, Antonio, Wang, Caihong, De Nolf, Clint, Vanhee, Stijn, Bujko, Anna, Chai, Qingqing, Isnard Petit, Patricia, Jorssen, Joseph, Van Gassen, Sofie, Saeys, Yvan, Korman, Alan J., Aerts, Stein, Scott, Charlotte, Lambrecht, Bart, Zumsteg, Anna Brotcke, Janssens, Sophie, Hochepied, Tino, De Winter, Seppe, Morel, Ariane, Schuijs, Martijn, Vanheerswynghels, Manon, Vandamme, Niels, Desmet, Christophe, De Leeuw, Elisabeth, De Prijck, Sofie, Schetters, Sjoerd, Sônego, Fabiane, Thielemans, Flore, Rogiers, Ilse, Courtois, Rachel, Bosteels, Victor, D'Hont, Jinke, Voet, Sofie, Van der Borght, Katrien, Vivier, Eric, Scott, Charlotte L., Corti, Davide, Baptista, Antonio P., Schmid, Michael A., Augier, Séverine, Hammad, Hamida, Elewaut, Dirk, Van Moorleghem, Justine, Lambrecht, Bart N., Van Den Eeckhout, Bram, Browaeys, Robin, Verwaerde, Stijn   +55 more
core   +1 more source

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

Transfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza, Thamy Caroline Silva, Mateus Domentino, Marina Cavalcanti Albuquerque Veiga Conrado, João Vitor Bernardo Oliveira, Felipe Augusto Rós, Caroline Gabe, Elyse Moritz, Akemi Chiba, Paula Villaça, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Dante Langhi, Carla Luana Dinardo   +14 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source