Results 41 to 50 of about 24,384 (198)

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression.

PLoS ONE, 2018
Because human epidermal growth factor-like receptor (HER) 2 is expressed on the surface of human pancreatic carcinoma cells to varying degrees, trastuzumab, an anti-HER2 monoclonal antibody (mAb), is expected to exert antibody-dependent, natural killer ...
Takushi Masu, Masanori Atsukawa, Katsuhisa Nakatsuka, Masumi Shimizu, Daishu Miura, Taeang Arai, Hirotomo Harimoto, Chisa Kondo, Keiko Kaneko, Seiji Futagami, Chiaki Kawamoto, Hidemi Takahashi, Katsuhiko Iwakiri   +12 more
doaj   +1 more source

Non-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromatography-mass spectrometry

mAbs, 2022
Antibodies facilitate targeted cell killing by engaging with immune cells such as natural killer cells through weak binding interactions with Fcγ receptors on the cell surface.
Daniel W. Woodall, Thomas M. Dillon, Kevin Kalenian, Rupa Padaki, Scott Kuhns, David J. Semin, Pavel V. Bondarenko   +6 more
doaj   +1 more source

An Intuitive Automated Modelling Interface for Systems Biology

, 2009
We introduce a natural language interface for building stochastic pi calculus models of biological systems. In this language, complex constructs describing biochemical events are built from basic primitives of association, dissociation and transformation.
Emmanuelle Caron, Luca Cardelli, Ozan Kahramanoğulları, S. Barry Cooper, Vincent Danos   +4 more
core   +4 more sources

Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes [PDF]

, 2000
IgM is the first antibody to be produced in a humoral immune response and plays an important role in the primary stages of immunity. Here we describe a mouse Fc receptor, designated Fcalpha/muR, and its human homolog, that bind both IgM and IgA with ...
Endo Yuichi, Fujita Teizo, Helen J. Eyre, Hiroyama Takashi, Lanier L. Lewis, Miyabayashi Tomoyuki, Nakauchi Hiromitsu, Nakayama Eiichi, Osawa Mitsujiro, Phillips H. Joseph, Sakamoto Norihisa, Sakano Seiji, Shibuya Akira, Shibuya Kazuko, Shimizu Yoshio, Sutherland R. Grant, Tsuji Takao, 渋谷 和子, 渋谷 彰   +18 more
core   +1 more source

Complement-mediated ADCP as a distinct and finite cytotoxic mechanism of monoclonal antibodies

Frontiers in Immunology
IntroductionMacrophage phagocytosis is a major cytotoxic mechanism for therapeutic monoclonal antibodies (mAbs) that opsonize target cells. This antibody-dependent cellular phagocytosis (ADCP) can occur via the Fcγ or complement pathways, but the ...
Carly M. Van Wagoner, Carly M. Van Wagoner, Jonathan J. Pinney, Hanna M. Sovinski, Brett P. Ransegnola, Brett P. Ransegnola, Nydia Jaimes-Delgadillo, Nydia Jaimes-Delgadillo, Charles C. Chu, Charles C. Chu, Clive S. Zent, Clive S. Zent, Michael R. Elliott, Michael R. Elliott   +13 more
doaj   +1 more source

Phosphoinositides and engulfment [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108686/1/cmi12334 ...
Swanson, Joel A.
core   +1 more source

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma [PDF]

, 2017
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors.
Alama, Alexiou, Amarante-Mendes, Ashkenazi, Ashkenazi, Ashkenazi, Borad, Botter, Campanacci, Chan, Chawla, Chirgwin, Dine, Duan, Ferrari, Goltzman, Goltzman, Goltzman, Gralow, He, Herbst, Holland, Holland, Kindler, Labrinidis, Liapis, Liapis, Link, Lustberg, Miharada, Mundy, Pringle, Robak, Saeter, Soria, Takeda, Tang, Taube, Wilson, Wojtkowiak, Yang, Younes, Zinonos   +42 more
core   +1 more source

Alga-made anti-Hepatitis B antibody binds to human Fcγ receptors. [PDF]

, 2017
Microalgae are unicellular eukaryotic organisms which represent an emerging alternative to other cell biofactories commonly used to produce monoclonal antibodies.
Alessandri, Allhorn, Barb, Barrera, Bhatnagar, Bortolotti, Bruckner, Bruhns, Castilho, Chanput, Chung, Daëron, Decker, Demain, Desjarlais, Dicker, Dickson, Elvin, Ferrara, Fleit, Frostell, Goetze, Greenwood, Haryadi, Hayes, Heider, Hempel, Hempel, Hempel, Hempel, Hossler, Houde, Iida, Jayapal, Jez, Jiang, Ju, Jung, Kanda, Kelley, Kober, Krapp, Lauc, Lingg, Mathieu-Rivet, Mayfield, Pollara, Qiu, Reski, Rosales-Mendoza, Rudd, Sack, Schwab, Shields, Shinkawa, Sondermann, Stern, Strohl, Tran, Tran, Tran, Tsuchiya, van de Winkel, Vanier, Varki, Walsh, Warnatz, Wright, Wurm, Yao, Yeap, Yu, Zeitlin, Zhang, Zhou   +74 more
core   +3 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source