Results 1 to 10 of about 446,467 (185)

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor [PDF]

Nature Communications
Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR ...
Teressa M. Shaw, Devra Huey, Makky Mousa-Makky, Jared Compaleo, Kylie Nennig, Aadit P. Shah, Fei Jiang, Xueer Qiu, Devon Klipsic, Raymond R. R. Rowland, Igor I. Slukvin, Meagan E. Sullender, Megan T. Baldridge, Haichang Li, Cody J. Warren, Adam L. Bailey   +15 more
doaj   +2 more sources

Impact of Neonatal Fc Receptor on Transferrin Receptor Antibody Fusion Protein Pharmacokinetics [PDF]

Pharmaceutics
Background: Transferrin receptor-targeting monoclonal antibodies (TfRMAbs) enhance brain drug delivery by facilitating TfR-mediated transcytosis across the blood–brain barrier (BBB).
Adenike Oyegbesan, Nataraj Jagadeesan, Devaraj V. Chandrashekar, Rachita K. Sumbria   +3 more
doaj   +2 more sources

Development of HEK293T-produced recombinant receptor-Fc proteins as potential candidates against canine distemper virus

Frontiers in Veterinary Science, 2023
Canine distemper (CD) is a highly contagious viral disease worldwide. Although live attenuated vaccine is available as a preventive measure against the disease, cases of vaccination failure highlight the importance of potential alternative agent against ...
Lingling Song, Lingling Song, Lingling Song, Hu Shan, Hu Shan, Hu Shan, Juan Huang, Juan Huang, Juan Huang   +8 more
doaj   +1 more source

Next Generation CD40 Agonistic Antibodies for Cancer Immunotherapy

Frontiers in Immunology, 2022
The clinical use of anti-CD40 agonist monoclonal antibodies (mAbs) is aimed at recruiting the immune system to fight the tumor cells. This approach has been demonstrated to be effective in various preclinical models.
Ran Salomon, Rony Dahan
doaj   +1 more source

A Quantitative Approach to Unravel the Role of Host Genetics in IgG-FcγR Complex Formation After Vaccination

Frontiers in Immunology, 2022
Fc-mediated immune functions have been correlated with protection in the RV144 HIV vaccine trial and are important for immunity to a range of pathogens. IgG antibodies (Abs) that form complexes with Fc receptors (FcRs) on innate immune cells can activate
Melissa M. Lemke, Robert M. Theisen, Emily R. Bozich, Milla R. McLean, Christina Y. Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, Bruce D. Wines, Bruce D. Wines, P. Mark Hogarth, P. Mark Hogarth, P. Mark Hogarth, Stephen J. Kent, Stephen J. Kent, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold   +20 more
doaj   +1 more source

Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions

iScience, 2023
Summary: The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely ...
Yannic C. Bartsch, Deniz Cizmeci, Jaewon Kang, Hailong Gao, Wei Shi, Abishek Chandrashekar, Ai-ris Y. Collier, Bing Chen, Dan H. Barouch, Galit Alter   +9 more
doaj   +1 more source

No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells. [PDF]

PLoS ONE, 2013
Myeloid cells express the TNF family ligands BAFF/BLyS and APRIL, which exert their effects on B cells at different stages of differentiation via the receptors BAFFR, TACI (Transmembrane Activator and CAML-Interactor) and/or BCMA (B Cell Maturation ...
Josquin Nys, Cristian R Smulski, Aubry Tardivel, Laure Willen, Christine Kowalczyk, Olivier Donzé, Bertrand Huard, Henry Hess, Pascal Schneider   +8 more
doaj   +1 more source

281 Fc gamma receptor crosslinking promotes antibody-induced LILRB4 internalization and immune regulation of acute monocytic leukemia

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: The aims of this study were to: 1) determine the involvement of each Fc gamma receptor isoform in antibody-mediated crosslinking and internalization of LILRB4 in acute monocytic leukemia and 2) elucidate the role of this crosslinking ...
Joshua Morse, Xun Gui, Mi Deng, Cheng Cheng Zhang, Ningyan Zhang, Zhiqiang An   +5 more
doaj   +1 more source

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Frontiers in Immunology, 2022
IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc
Brittani M. Barrows, Brittani M. Barrows, Brittani M. Barrows, Shelly J. Krebs, Shelly J. Krebs, Ningbo Jian, Ningbo Jian, Michelle Zemil, Michelle Zemil, Bonnie M. Slike, Bonnie M. Slike, Vincent Dussupt, Vincent Dussupt, Ursula Tran, Ursula Tran, Letzibeth Mendez-Rivera, Letzibeth Mendez-Rivera, David Chang, David Chang, Anne Marie O’Sullivan, Anne Marie O’Sullivan, Brendan Mann, Brendan Mann, Eric Sanders-Buell, Eric Sanders-Buell, Zhanna Shubin, Zhanna Shubin, Matt Creegan, Matt Creegan, Dominic Paquin-Proulx, Dominic Paquin-Proulx, Philip Ehrenberg, Philip Ehrenberg, Agnes Laurence-Chenine, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Michael A. Eller, Guido Ferrari, Merlin Robb, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek, Lindsay Wieczorek   +47 more
doaj   +1 more source

Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone

Haematologica, 2012
Background Fc gamma receptor polymorphisms were linked to outcome in follicular lymphoma patients treated with single-agent rituximab, an anti-CD20 monoclonal antibody.
Daniel O. Persky, David Dornan, Bryan H. Goldman, Rita M. Braziel, Richard I. Fisher, Michael LeBlanc, David G. Maloney, Oliver W. Press, Thomas P. Miller, Lisa M. Rimsza   +9 more
doaj   +1 more source