Altered executive control network connectivity in anti‐NMDA receptor encephalitis
Annals of Clinical and Translational Neurology, 2022 Objective The goal of this study was to examine whether the static functional connectivity (FC) of the executive control network (ECN) and the temporal properties of dynamic FC states in the ECN can characterize the underlying nature of anti‐N‐methyl‐d ...
Zhongqin Chen +5 more
doaj +1 more source
Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection [PDF]
, 2019 Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Ballegeer, Marlies +10 more
core +2 more sources
Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa [PDF]
, 2016 The Fc region of Immunoglobulin G (IgG) initiates inflammatory responses such as antibody-dependent cell-mediated cytotoxicity (ADCC) through binding to activating Fc receptors (FcγRI, FcγRIIa, FcγRIIIa).
Ahmed, Alysia A. +3 more
core +2 more sources
Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G [PDF]
, 1999 Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding.
Bjorkman, Pamela J. +5 more
core +1 more source
The Neonatal Fc Receptor (FcRn): A Misnomer?
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
doaj +1 more source
Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. [PDF]
PLoS ONE, 2010 LAIR-1 (Leukocyte Associated Ig-like Receptor -1) is a collagen receptor that functions as an inhibitory receptor on immune cells. It has a soluble family member, LAIR-2, that also binds collagen and can interfere with LAIR-1/collagen interactions ...
Peter J Lenting +4 more
doaj +1 more source
The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization.
PLoS ONE, 2007 Herpesviruses maintain long-term infectivity without marked antigenic variation. They must therefore evade neutralization by other means. Immune sera block murine gammaherpesvirus-68 (MHV-68) infection of fibroblasts, but fail to block and even enhance ...
Laurent Gillet +3 more
doaj +1 more source
OncoImmunology, 2017 Natural killer (NK) cells are innate immune effector cells that play a crucial role in immune surveillance and the destruction of cancer cells. NK cells express a low-affinity receptor for the Fc or constant region of immunoglobulin G (FcγRIIIa) and ...
Elizabeth L. McMichael +13 more
doaj +1 more source
Fc-Engineering for Modulated Effector Functions—Improving Antibodies for Cancer Treatment
Antibodies, 2020 The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage innate immune effectors through interactions mediated by their fragment crystallizable (Fc) domain.
Rena Liu +4 more
doaj +1 more source
Dopamine D 4 Receptor-Deficient Mice Display Cortical Hyperexcitability [PDF]
, 2001 The dopamine D(4) receptor (D(4)R) is predominantly expressed in the frontal cortex (FC), a brain region that receives dense input from midbrain dopamine (DA) neurons and is associated with cognitive and emotional processes.
Ariano, Marjorie A. +11 more
core +1 more source