Results 11 to 20 of about 990,352 (302)
Annual Review of Immunology, 2001 Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions of these receptors in diverse biological systems. The role of activating FcγRs in providing a
Jeffrey V. Ravetch, Silvia Bolland
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Brain Invaders: IgG and IgG receptors in schizophrenia [PDF]
, 2019 Elevated proinflammatory cytokines are found in the brain and the blood from schizophrenia cases and are used to define the “high” and “low” inflammatory biotypes. Cytokines elevated in schizophrenia mediate IgG release and effector functions.
Glass, Lara
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IgG binding characteristics of ferret Fcγ receptors
mAbsStudies in animal models are essential to expanding the scope of interventions evaluated for safety, immunogenicity, and efficacy in clinical trials.
Xiaoxuan Ge +8 more
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IgG and Fcγ Receptors in Intestinal Immunity and Inflammation [PDF]
Frontiers in Immunology, 2019 Fcγ receptors (FcγR) are cell surface glycoproteins that mediate cellular effector functions of immunoglobulin G (IgG) antibodies. Genetic variation in FcγR genes can influence susceptibility to a variety of antibody-mediated autoimmune and inflammatory ...
Tomas Castro-Dopico +3 more
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NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]
, 2014 There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L. +5 more
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, 1991 Serum levels of Candida-specific IgG(4) antibodies were examined in 66 patients with bronchial asthma, relating to patient age and asthma severity. 1.
Tanizaki, Yoshiro +7 more
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Impact of Plasma Membrane Domains on IgG Fc Receptor Function
Frontiers in Immunology, 2020 Lipid cell membranes not only represent the physical boundaries of cells. They also actively participate in many cellular processes. This contribution is facilitated by highly complex mixtures of different lipids and incorporation of various membrane ...
Sibel Kara +12 more
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Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis.
PLoS ONE, 2013 Intravenous immunoglobulin has long been used in treating autoimmune diseases, although mechanisms remain uncertain. Activating Fcγ receptors are receptors of IgG and reported to be essential in intravenous immunoglobulin (IVIG) therapy.
Wai Po Chong +7 more
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Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to
, 2009 Background Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control.
Thor G Theander +34 more
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The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]
, 2007 Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Periasamy Selvaraj +2 more
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