Results 11 to 20 of about 296,832 (268)
Frontiers in Immunology, 2014 The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn and TRIM21.
Caitlin Margaret Gillis +8 more
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Impact of Plasma Membrane Domains on IgG Fc Receptor Function
Frontiers in Immunology, 2020 Lipid cell membranes not only represent the physical boundaries of cells. They also actively participate in many cellular processes. This contribution is facilitated by highly complex mixtures of different lipids and incorporation of various membrane ...
Sibel Kara +12 more
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Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis.
PLoS ONE, 2013 Intravenous immunoglobulin has long been used in treating autoimmune diseases, although mechanisms remain uncertain. Activating Fcγ receptors are receptors of IgG and reported to be essential in intravenous immunoglobulin (IVIG) therapy.
Wai Po Chong +7 more
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Receptor-mediated transport of IgG. [PDF]
The Journal of cell biology, 1984 The intestinal epithelium of the neonatal rat is a model system for the study of receptor-mediated endocytosis in which large amounts of IgG are transferred intact across polarized cells. This review summarizes the ultrastructural pathway followed by IgG during cellular transit and several important properties of the membrane receptor that recognizes ...
R, Rodewald, J P, Kraehenbuhl
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Immunomodulation by IVIg and the role of Fc-gamma receptors: classic mechanisms of action after all?
Frontiers in Immunology, 2015 Intravenous IgG (IVIg) contains polyclonal IgG from thousands of donors. It is administered at a low dose at regular intervals as antibody replacement therapy and at a higher dose as immunomodulatory treatment in various auto-immune or auto-inflammatory ...
Sietse Quirijn Nagelkerke +2 more
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Neonatal Fc receptor and IgG-based therapeutics [PDF]
mAbs, 2011 The majority of potent new biologics today are IgG-based molecules that have demonstrated tissue-targeting specificity with favorable clinical response. Several factors determine the efficacy of these products, including target specificity, serum half-life and effector functions via complement-dependent cytotoxicity, antibody-dependent cell-mediated ...
Timothy T, Kuo, Victoria G, Aveson
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The role of FcRn in antigen presentation
Frontiers in Immunology, 2014 Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to
Kristi eBaker +4 more
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IgG Isolated from LP-BM5 Infected Mouse Brain Activates Ionotropic Glutamate Receptors
Neurobiology of Disease, 2001 Biochemical and immunological studies have shown that mice infected with LP-BM5 virus develop antibodies to ionotropic glutamate receptors. Here, IgG isolated from brain of infected mice has been tested electrophysiologically on cultured rat cortical and
Anthony S. Basile +5 more
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A Comparison of Natural and Therapeutic Anti-IgE Antibodies
AntibodiesImmunoglobulin E (IgE) plays a critical role for the immune system, fighting against parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation, it can cause allergic reactions, including anaphylaxis, through a process ...
Monique Vogel, Paul Engeroff
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Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population
Frontiers in Immunology, 2020 Repeated infections by Plasmodium falciparum result in a humoral response that could reduce disease symptoms and prevent the development of clinical malaria.
Mireille Ahou Amiah +6 more
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