Results 191 to 200 of about 1,036,661 (382)

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

The Escherichia coli ts8 mutation is an allele of fda, the gene encoding fructose-1,6-diphosphate aldolase

, 1991
Mitchell Singer, P Rossmiessl, B M Cali, H. Liebke, Carol A. Gross   +4 more
openalex   +1 more source

FDA Preemption of State Tort Law in Drug Regulation: Finding the Sweet Spot [PDF]

The positive and normative relationships between FDA regulation of pharmaceutical drugs and state tort law have gained much attention in recent years, with FDA aggressively asserting preemptive effect, some state courts resisting, and the U.S.
Schuck, Peter H.
core   +1 more source

A Comprehensive Review of Clinical Studies on Bacterial Cellulose: From the Earliest Uses to Contemporary Innovations

Advanced Healthcare Materials, EarlyView.
Bacterial cellulose has undergone a transformative journey from early applications to its role in advanced regenerative medicine. The review has a pedagogical ambition, offering clear pathways for future research and clinical adoption. Harmonizing regulatory standards and conducting larger, well‐designed clinical trials with standardized endpoints will
Thomas Meslier, Justin Christopher D'Antin, Gemma Julio, Anna Roig   +3 more
wiley   +1 more source

FDA and EPA setbacks, fetal nicotine, ASH Thailand and UK, tennis shame, Australian documents, Corporate Activity Project, and 2100 quotes [PDF]

, 1998
J Cannon
openalex   +1 more source

From the FDA: FDA approves Keppra

Journal of Osteopathic Medicine, 1999
openaire   +2 more sources

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 11

Journal of Comparative Effectiveness Research, 2023
Ben Bray, Sreeram V Ramagopalan
doaj   +1 more source

How AI is used in FDA-authorized medical devices: a taxonomy across 1,016 authorizations. [PDF]

NPJ Digit Med
Singh R, Bapna M, Diab AR, Ruiz ES, Lotter W.   +4 more
europepmc   +1 more source

FDA Approves First Urine-Based HIV Test [PDF]

, 1996
Veronica Johnston, Terri Yablonsky
openalex   +1 more source