Results 211 to 220 of about 551,808 (299)

U.S. Food & Drug Administration (FDA) Daily Digest Bulletin

, 2013
U.S. Food & Drug Administration (FDA)
core  

Emerging Artificial Intelligence Tools for the Screening of Structural and Valvular Heart Disease. [PDF]

Curr Heart Fail Rep
Abbaoui Y, Nolin-Lapalme A, Morisset J, El Adib I, Genereux P, Poterucha TJ, Elias P, Yao X, Avram R.   +8 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

FDA Inspections Boston Dec 03-04

, 2015
FDA updates
core  

Cybersecurity breaches in medical devices: analyzing FDA safety communications in response to patient security concerns. [PDF]

Front Digit Health
Menon V.
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

FDA Inspections : 12 RAC credit : Two weeks to go

, 2015
FDA updates
core  

Accessibility of Biologic Drugs in Morocco: Comparison with FDA and EMA Approvals (2015-2025). [PDF]

J Mark Access Health Policy
Charrak M, Cherrah Y, Serragui S.
europepmc   +1 more source