Results 231 to 240 of about 551,808 (299)

The pH factor: unraveling drug-drug interactions in protein kinase inhibitors through the regulatory lens. [PDF]

Transl Clin Pharmacol
Stankeviciute S, Tsai A, Rayad N, Kruse M.   +3 more
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Enzymatic Laccase Nanoreactors Induce Apoptosis in MOLT-4-ALL Cells and Activate Prodrugs in a Synergetic Effect. [PDF]

Blood Lymphat Cancer
Medrano-Villagómez CA, Loredo-García E, Gasperin-Bulbarela J, Vazquez-Duhalt R.   +3 more
europepmc   +1 more source

From Models to Medicines: A Narrative History and Regulatory Perspective on the Translational Impact of Model-Informed Drug Development (MIDD). [PDF]

Clin Transl Sci
Zineh I.
europepmc   +1 more source

FDA Approval of Donanemab-azbt: A New Dawn in Alzheimer's Disease Treatment. [PDF]

Health Sci Rep
Riaz R, Fatima M, Ramzan S, Rathi D, Fatima F, Farooq M, Shaukat A, Khaliq N, Akilimali A.   +8 more
europepmc   +1 more source

Tuberculosis Infection Screening Recommendations for Targeted Immunotherapies: Comparison of US Prescribing Information, Clinical Resources, and Quality Measures. [PDF]

Clin Infect Dis
Murrill MT, Velásquez GE, Szumowski JD, Phillips A, Kim A, Yazdany J, Roberts ET, Habib AR, Batlle HR, Salazar J, Minter DJ, Louie JK, Ernst JD.   +12 more
europepmc   +1 more source

From Precision to Personalized: Catalyzing AI-Enabled Innovation in Drug Development. [PDF]

Clin Transl Sci
Subbaswamy A, Dunn A, Langevin B, Lee S, Gopalakrishnan M, Gobburu JVS.   +5 more
europepmc   +1 more source

Analysis of Trends in FDA-Recalled Hip Arthroplasty Devices: A Retrospective Review. [PDF]

JB JS Open Access
Lorimer LPA, Hali K, Raspanti J, Keshen S, Ravi B, Poultsides LA, Lex JR, Stavropoulos NA, Babis GC.   +8 more
europepmc   +1 more source

How to survive FDA Inspections : Learn From Expert

, 2015
FDA updates
core  

FDA Updates for Health Professionals

, 2012
U.S. Food & Drug Administration (FDA)
core