Results 61 to 70 of about 551,808 (299)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper +25 more
wiley +1 more source
Доказана генетическая предрасположенность к хронической боли
Медицинский совет, 2014 Обнаружены гены, определяющие чувствительность человека к хронической боли, сообщает Medical News Today по материалам ежегодной конференции Американской академии неврологии в Филадельфии.
Editorial Article
doaj +1 more source
Valid cardiac biomarkers. Part I
Кардиоваскулярная терапия и профилактика, 2020 Biomarkers are widely used for the diagnosing of diseases, evaluation of their severity, prediction of outcomes, and for monitoring the effectiveness and safety of targeted therapy.
V. A. Metelskaya, N. G. Gumanova
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
The Effects of Product Liability Exemption in the Presence of the FDA [PDF]
In the United States, drugs are jointly regulated by the US Food and Drug Administration, which oversees premarket clinical trials designed to ensure drug safety and efficacy, and the liability system, which allows patients to sue manufacturers for ...
Eric C. Sun +2 more
core
Eliminate Dishonesties in the FDA Food Label
, 2012 Stricter requirements for labeling regulations could eliminate dishonesties in FDA food labeling, according to Adam Finkel, ScD, University of Pennsylvania. Finkel proposes four key ways the FDA could amend its labeling regulations.
Finkel, Adam
core +1 more source
Flow Direction Algorithm (FDA): A Novel Optimization Approach for Solving Optimization Problems
, 2021 The present study aimed to propose a new optimization algorithm named Flow Direction Algorithm (FDA), which is a physics-based algorithm. The FDA algorithm mimics the flow direction to the outlet point with the lowest height in a drainage basin. In other
Mirjalili, S +3 more
core +1 more source
В целом пациенты удовлетворены лечением послеоперационных болей
Медицинский совет, 2014 Пациенты, принимающие непосредственное участие в принятии решений, связанных с лечением послеоперационных болей, в большей степени удовлетворены проводимой терапией.
Editorial Article
doaj +1 more source