Results 81 to 90 of about 1,036,661 (382)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Pure Spinors, Free Differential Algebras, and the Supermembrane [PDF]

, 2006
The lagrangian formalism for the supermembrane in any 11d supergravity background is constructed in the pure spinor framework. Our gauge-fixed action is manifestly BRST, supersymmetric, and 3d Lorentz invariant. The relation between the Free Differential
Aisaka, Aisaka, Anguelova, Anguelova, Anselmi, Bandos, Bandos, Bars, Bars, Baulieu, Bergshoeff, Bergshoeff, Bergshoeff, Berkovits, Berkovits, Berkovits, Berkovits, Billo, Castellani, Castellani, Castellani, Castellani, Castellani, Castellani, Castellani, D'Auria, Dall'Agata, de Wit, Duff, Duff, Duff, Duff, Fre, Fré, Fré, Fré, Goto, Grassi, Grassi, Grassi, Grassi, Grassi, Green, Green, Harvey, Hatsuda, Mafra, Matone, Oda, Pesando, Pietro Antonio Grassi, Pietro Fré, Plefka, Polyakov, Sullivan, Tonin   +55 more
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Bioactivity of nanosilver in Caenorhabditis elegans: Effects of size, coat, and shape

Toxicology Reports, 2014
The in vivo toxicity to eukaryotes of nanosilver (AgNP) spheres and plates in two sizes each was assessed using the simple model organism Caenorhabditis elegans.
Piper Reid Hunt, Zachary Keltner, Xiugong Gao, Steven J. Oldenburg, Priyanka Bushana, Nicholas Olejnik, Robert L. Sprando   +6 more
doaj   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Development of Luciferase Immunoprecipitation Systems (LIPS) Assay to Detect IgG Antibodies against Human Respiratory Syncytial Virus G-Glycoprotein

Vaccines, 2019
Respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in infants and the elderly. Although there is no licensed vaccine, RSV-F and -G glycoproteins are targets for vaccine development and therapeutics. We developed an assay that
Roberta Lynne Crim, Sangeeta Kumari, Priyanka Jayanti, Susette Audet, Ashwin Kulkarni, Judy Beeler   +5 more
doaj   +1 more source

Functional parameters of spermatozoa obtained by a new selection device

FEBS Open Bio, EarlyView.
This study compares density gradient centrifugation and the LensHooke CA0™ device for sperm separation. DGC requires multiple steps, specialized equipment, and technical expertise. In contrast, the CA0 device offers key practical and methodological advantages, resulting in a faster, simpler, and more affordable sperm selection method.
Julio C. Chávez, Paulina Torres, Gabriela Carrasquel‐Martínez, María G. Figueroa‐Méndez, Diana Flores, Lina Villar, Israel Maldonado, Marcela B. Trevino, Claudia Treviño   +8 more
wiley   +1 more source

Proteomic insights into dual-species biofilm formation of E. coli and E. faecalis on urinary catheters

Scientific Reports
Infections associated with urinary catheters are often caused by biofilms composed of various bacterial species that form on the catheters’ surfaces.
Kidon Sung, Miseon Park, Ohgew Kweon, Angel Paredes, Alena Savenka, Saeed A Khan   +5 more
doaj   +1 more source

Don\u27t Try This at Home: The FDA\u27s Restrictive Regulation of Home-Testing Devices [PDF]

, 2017
Over the past forty years, the Food and Drug Administration (FDA) has successfully restricted consumers\u27 access to home-testing applications based on the notion that it should protect individuals from their own reactions to test results. In the 1970s,
Shelby Baird
core   +1 more source

Fermionic extensions of the Standard Model in light of the Higgs couplings [PDF]

, 2015
As the Higgs boson properties settle, the constraints on the Standard Model extensions tighten. We consider all possible new fermions that can couple to the Higgs, inspecting sets of up to four chiral multiplets.
Bizot, Nicolas, Frigerio, Michele
core   +2 more sources