Results 21 to 30 of about 467,233 (247)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Miguel de Unamuno: la fe trascendental

Revista Espiga, 2013
El presente ensayo filosófico no solamente busca contribuir en el conocimiento, enriquecimiento o realimentación del pensamiento del filósofo vasco, sino especialmente colaborar en definir ese aspecto metafísico, que, en todo filósofo, coexiste con su ...
Ricardo Antonio Villalobos Paniagua
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

EVALUASI CAPAIAN PEMBERIAN FE PADA REMAJA PUTRI TULUNGAGUNG MELALUI KEGIATAN MAGANG MAHASISWA

Journal of Community Mental Health and Public Policy, 2022
Introduction: Low Fe coverage in young women can cause health problems such as anemia. The prevalence of anemia in Indonesia is higher in adolescent girls than in adolescent boys by 27.2%.
Widadari Intan Rujaby, Trias Mahmudiono, Bekti Krisdyana   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

La Repetitio de Fide Catholica de Juan de Segovia. Análisis y comentario

Estudios Eclesiásticos, 2019
Juan de Segovia ocupa un lugar destacado entre los Padres sinodales que han marcado el rumbo del concilio de Basilea (1431-1449). Se comprometió y posicionó a favor de la superioridad del concilio sobre el papa.
Santiago Madrigal Terrazas, SJ
doaj  

Kierkegaard socrático. Estética, ética y religión

Estudios Sociales Contemporáneos
El objetivo de este trabajo es ofrecer un panorama del importante significado que implicó el viaje y la estancia de Kierkegaard en Berlín en 1843, resumiendo el clima intelectual de esta ciudad durante el tiempo que este permaneció allí.
Carlos Alberto Navarro Fuentes
doaj   +1 more source

State-ownership and bank risk: A case of Vietnamese commercial banks

Ho Chi Minh City Open University Journal of Science - Economics and Business Administration, 2020
The paper aims to verify the impact of state-ownership on banks’ risks at Vietnamese commercial banks. Based on the survey data of 31 commercial banks in Vietnam from 2007 to 2018, the empirical result shows that the state-ownership in the Vietnamese ...
Nguyen Thanh Hung, Pham Phu Quoc
doaj   +1 more source