Results 61 to 70 of about 3,343,046 (404)
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
The Impact of Adverse Childhood Experiences on Asthma Severity in US Adults
Medical SciencesBackground/objectives: The association between adverse childhood experiences (ACEs) and asthma severity among United States (US) adults with asthma has not been well documented.
Chukwuemeka E. Ogbu +4 more
doaj +1 more source
Sketching the Power of Machine Learning to Decrypt a Neural Systems Model of Behavior
Brain Sciences, 2019 Uncovering brain-behavior mechanisms is the ultimate goal of neuroscience. A formidable amount of discoveries has been made in the past 50 years, but the very essence of brain-behavior mechanisms still escapes us.
Monique Ernst +4 more
doaj +1 more source
Parent\u2019s perception of children\u2019s fear: from FSSC-IT to FSSC-PP [PDF]
, 2015 Studies involving parents' reports about children's fears and multiple informant comparisons are less extended than investigations on children's self-reporting fear schedules.
Dazzi, Carla +4 more
core +2 more sources
Current Biology, 2013 Each of us has felt afraid, and we can all recognize fear in many animal species. Yet there is no consensus in the scientific study of fear. Some argue that 'fear' is a psychological construct rather than something discoverable through scientific investigation.
openaire +5 more sources
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source
A Critical-Historical Review of Program Evaluation and the Emerging Motif ‘Evaluation Science’
Journal of MultiDisciplinary Evaluation, 2020 Background: It is important to distinguish between evaluation as an inherent, automatic, affective process and Program Evaluation (Evaluation, with capitalised ‘E’) as an institution, and equally important to consider what a good understanding of ...
William James Fear
doaj +1 more source
Avoidant symptoms in PTSD predict fear circuit activation during multimodal fear extinction [PDF]
, 2013 Convergent evidence suggests that individuals with posttraumatic stress disorder (PTSD) exhibit exaggerated avoidance behaviors as well as abnormalities in Pavlonian fear conditioning.
Israel eLiberzon +4 more
core +2 more sources
Psychophysiological modelling and the measurement of fear conditioning [PDF]
, 2020 Quantification of fear conditioning is paramount to many clinical and translational studies on aversive learning. Various measures of fear conditioning co-exist, including different observables and different methods of pre-processing.
Bach, D., Melinscak, F.
core +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source