Results 71 to 80 of about 19,755 (259)

Plasticity of fear and safety neurons of the amygdala in response to fear extinction

Frontiers in Behavioral Neuroscience, 2015
Fear inhibition learning induces plasticity and remodeling of circuits within the amygdala. Most studies examine these changes in nondiscriminative fear conditioning paradigms.
Susan eSangha, Susan eSangha
doaj   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Aminal‐linked Covalent Organic Frameworks for Light Energy Upconversion

Angewandte Chemie, EarlyView.
Aminal‐linked covalent organic frameworks incorporating anthracene units are introduced as solid‐state platforms for triplet–triplet annihilation upconversion. The crystalline materials retain chromophore electronic properties and exhibit fluorescence quantum yields of up to 40%.
Mateusz Brzeziński, Agata Tyszka‐Gumkowska, Aleksander Gorski, Marek J. Potrzebowski, Tomasz Polczyk, Wojciech Wegner, Sylwester Gawinkowski, Jakub Ostapko   +7 more
wiley   +2 more sources

The effects of spaced versus massed extinction training on extinction retention of conditioned fear learning in male rats

Frontiers in Behavioral Neuroscience
IntroductionExtinction learning of conditioned fear behavior has been used as a translational model to study human fear-, anxiety-, trauma-, and stressor-related disorders and their underlying neurobiology in animal models because the underlying neural ...
Grant W. LeVasseur, Timothy Cilley, Michelle Szewczuk, Shane A. Perrine, Seth D. Norrholm   +4 more
doaj   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Attentional Control and Fear Extinction in Subclinical Fear: An Exploratory Study

Frontiers in Psychology, 2017
Attentional control (AC) and fear extinction learning are known to be involved in pathological anxiety. In this study we explored whether individual differences in non-emotional AC were associated with individual differences in the magnitude and gradient
Eduard Forcadell, Eduard Forcadell, David Torrents-Rodas, David Torrents-Rodas, Devi Treen, Miquel A. Fullana, Miquel A. Fullana, Miquel A. Fullana, Miquel Tortella-Feliu, Miquel Tortella-Feliu   +9 more
doaj   +1 more source

Emerging Device Applications From Strong Light–Matter Interactions in 2D Materials

Advanced Science, EarlyView.
Two‐dimensional semiconductors enable extremely compact optoelectronic devices such as solar cells, sensors, LEDs, and lasers. Their strong light–matter interactions allow efficient light emission, detection, and energy conversion. This review article discusses the recent progress in integrating these materials with optical cavities and nanostructures ...
Janani Archana K, Kumar Shwetabh, Reyas Ali, Ramji Velayutham, Koustav Das, Abhishek Mondal, Prashant Kumar, Surendra B. Anantharaman   +7 more
wiley   +1 more source

An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits

Communications Biology
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we reveal its impact on the thalamic nucleus reuniens
Hoiyin Cheung, Tong-Zhou Yu, Xin Yi, Yan-Jiao Wu, Qi Wang, Xue Gu, Miao Xu, Meihua Cai, Wen Wen, Xin-Ni Li, Ying-Xiao Liu, Ying Sun, Jijian Zheng, Tian-Le Xu, Yan Luo, Ma-Zhong Zhang, Wei-Guang Li   +16 more
doaj   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source