Results 91 to 100 of about 176,181,179 (281)

Assessing the impact of a self-guided digital intervention for fear of cancer recurrence (iConquerFear) in ovarian cancer survivors: a pilot randomised waitlist-controlled trial

BMC Cancer
Background Approximately 50% of ovarian cancer (OC) survivors report fear of cancer recurrence/progression (FCR/P) as the most challenging aspect of living with cancer.
Verena S Wu, Allan ‘Ben’ Smith, Hayley Russell, Adeola Bamgboje-Ayodele, Lisa Beatty, Alison Pearce, Haryana Dhillon, Joanne Shaw, Jan Antony, Joanna Fardell, Anupama Pangeni, Cyril Dixon, Orlando Rincones, Laura Langdon, Daniel Costa, Afaf Girgis   +15 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

[Fear of progression in parents of children with cancer: adaptation of the Fear of Progression Questionnaire and correlates].

, 2015
Fear of Progression (FoP), the fear of further disease progression, is one of the most common psychological strains of chronically ill patients and can also be found in healthy partners of cancer patients. Parents of children with cancer are also at risk
Schepper, F;Abel, K;Herschbach, P;Christiansen, H;Mehnert, A;Martini, J
core   +1 more source

A feasibility study of the Mini-AFTER telephone intervention for the management of fear of recurrence in breast cancer survivors : a mixed-methods study protocol [PDF]

, 2017
This study has been funded by the breast cancer research charity Breast Cancer Now (Ref: 2015NovSP679).Background:  Fear of recurrence (FoR) is a major concern for patients following treatment for primary breast cancer, affecting 60–99% of breast cancer ...
Jo Armes, Fenlon, Deborah, Banks, Elspeth, Karen Scanlon, Steel, Emma, Cruickshank, Susanne, Emma Steel, Humphris, Gerald, Armes, Jo, Scanlon, Karen, Deborah Fenlon, Humphris, Gerry, Elspeth Banks, Gerald Humphris, Susanne Cruickshank, Humphris, Gerald; id_orcid   +15 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression

, 2014
[[abstract]]Esophageal cancer is an aggressive human malignancy with rising incidence in the developed world. The vascular endothelial growth factor VEGF-C makes crucial contributions to esophageal cancer progression that are not well understood. Here we
Hong, CC;Chen, PS;Chiou, J;Chiu, CF;Yang, CY;Hsiao, M;Chang, YW;Yu, YH;Hung, MC;Hsu, NW;Shiah, SG;Hsu, NY;Su, JL
core   +1 more source

Integrins in prostate cancer progression [PDF]

, 2008
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors.
H. L. Goel, J. Li, L. R Languino, Kogan, Sophia, Goel, Hira Lal, Li, Jing, S. Kogan, Languino, Lucia R.   +7 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source