Results 71 to 80 of about 176,181,179 (281)

An intervention for fear of progression in childhood cancer patients and their parents: feasibility and preliminary efficacy in a pilot randomised controlled trial

BMC Pediatrics
Background Fear of progression (FoP) is a significant psychosocial burden for children with cancer and their parents, influencing their quality of life (HRQoL) and emotional adjustment.
Jessy Herrmann, Laura Kern, Anja Santel, Kristina Herzog, Leonard Konstantin Kulisch, Christa Engelhardt-Lohrke, Rahel Hoffmann, Christiane Chen-Santel, Jörn-Sven Kühl, Florian Schepper   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian Cancer

, 2017
[[abstract]]Ovarian cancer spheroids constitute a metastatic niche for transcoelomic spread that also engenders drug resistance. Spheroid-forming cells express active STAT3 signaling and display stem cell-like properties that may contribute to ovarian ...
陳民瑋;Chen MW;Yang ST; Chien MH; Hua KT; Wu CJ;Hsiao SM; Lin H;Hsiao M;蘇振良;Wei LH, Chen, MW;Yang, ST;Chien, MH;Hua, KT;Wu, CJ;Hsiao, SM;Lin, H;Hsiao, M;Su, JL;Wei, LH   +1 more
core   +1 more source

Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls [PDF]

, 2017
PURPOSE: The current study determined the prevalence of severe fatigue in adolescent and young adult (AYA) cancer patients (aged 18-35 years at diagnosis) consulting a multidisciplinary AYA team in comparison with gender- and age-matched population-based
Suzanne E. J. Kaal, Jansen, R., Graaf, W.T.A. van der, Winette T. A. van der Graaf, Servaes, P., Petra Servaes, Knoop, H., Prins, JB, van der Graaf, WTA, Husson, O, Eveliene Manten-Horst, Manten-Horst, E., Husson, O., Poort, H., Kaal, S.E.J., Hans Knoop, Knoop, H, Servaes, P, Olga Husson, Kaal, SEJ, Judith B. Prins, Manten-Horst, E, Rosemarie Jansen, Poort, H, Prins, J.B., Hanneke Poort, Jansen, R   +26 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Illness perceptions, fear of progression and health-related quality of life during acute treatment and follow-up care in paediatric cancer patients and their parents: a cross-sectional study

BMC Psychology, 2023
Background This study examines the role of illness perceptions and fear of progression (FoP) in paediatric cancer patients and their parents for patient’s health-related quality of life (HRQoL), controlling for sociodemographic and medical variables.
Kristina Herzog, Florian Schepper, Thomas Pletschko, Jessy Herrmann, Mihaela Budich, Holger Christiansen, Meinolf Suttorp, Julia Martini   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Longitudinal patterns in fear of cancer progression in patients with rare, advanced cancers undergoing comprehensive tumour genomic profiling

, 2021
Longitudinal patterns in fear of cancer progression in patients with rare, advanced cancers undergoing comprehensive tumour genomic ...
P Butow (9896903), D Goldstein (7785062), B Biesecker (13514215), B Meiser (13403322), A Newson (13403349), J Kirk (7749590), MA Young (14548451), TE Schlub (14466573), K Tucker (9860336), K Vines (13743820), C Jacobs (9314690), N Bartley (13403331), MC Best (14452716), ML Ballinger (14452725), DM Thomas (9884240), CE Napier (14452719), F Müller (7783766), R Vines (13743817), I Juraskova (13403334), Jacqueline Savard (13093365)   +19 more
core  

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer [PDF]

, 2011
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility.
Richard R. Meehan, Caldwell Helen, Dubois-Marshall, Sylvie, Sylvie Dubois-Marshall, Helen Caldwell, Sims, Andrew H., Sims Andrew H., Elad Katz, Katz Elad, Elad Katz, Meehan Richard R., Meehan, Richard R, Richard R Meehan, Gautier Philippe, David J. Harrison, Richard R, Harrison David J., Gautier, Philippe, Dubois-Marshall Sylvie, Sims, Andrew H, Philippe Gautier, Harrison, David J, David J Harrison, Katz, Elad, Andrew H. Sims, Meehan, Richard R., Andrew H Sims, Caldwell, Helen, Harrison, David J., Harrison, David J.; id_orcid   +29 more
core   +1 more source