Results 101 to 110 of about 113,882 (286)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Experiences of diagnosis, stigma, culpability, and disclosure in male patients with hepatitis C virus: an interpretative phenomenological analysis [PDF]

, 2019
The current study aimed to explore the lived experience of patients with hepatitis C virus infection. Semi-structured interviews were conducted with seven male participants living with hepatitis C virus and were analysed using interpretative ...
Adele Dickson, Anna Krzeczkowska, Hopwood M, Lowe D, Paul Flowers, Peter Hayes, Poynard T, Smith JA, Stuenkel D, Tompkins CNE, Wasley A, Zoe Chouliara   +11 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

New insights into frequency and contents of fear of cancer progression/recurrence (FOP/FCR) in outpatients with colorectal carcinoma (CRC) receiving oral capecitabine: a pilot study at a comprehensive cancer center

Patient Preference and Adherence, 2017
Jochen Hefner,1 Sara Berberich,2 Elena Lanvers,3 Maria Sanning,2 Ann-Kathrin Steimer,2 Volker Kunzmann4 1Section of Psychosomatic Medicine, Department of Internal Medicine II, University of Wuerzburg, 2Faculty of Medicine, University of Wuerzburg ...
Hefner J, Berberich S, Lanvers E, Sanning M, Steimer A, Kunzmann V   +5 more
doaj  

Analysis on status of fear of disease progression in patients with nasopharyngeal carcinoma after 5 years discharged from hospital and its influencing factors

Huli yanjiu, 2020
ObjectiveThis paper investigated status quo on fear of disease progression in nasopharyngeal carcinoma patients after 5 years discharged from hospital,and analyzed its influencing factors.MethodsA total of 100 nasopharyngeal carcinoma patients(NPC ...
QIU Liyan, YANG Li
doaj  

Nurse's Spiritual Care Competencies to Patient with End Stage Breast Cancer [PDF]

, 2018
Cancer has many side effects on patient's physic and mostly on mental which may affect on their quality of life. Physically most patients feel fatigue, insomnia, anorexia, nausea, and vomit while mentally they feel emotional disturbances such as anxiety,
Anisa, N. R. (Nurul), Erika, K. A. (Kadek), Rachmawaty, R. (Rini)   +2 more
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Effects of the “Internet +” nursing model based on user profiling on postoperative recovery in breast cancer: A prospective randomized controlled clinical trial

International Journal of Nursing Sciences
Objectives: This study aimed to explore the effectiveness and advantages of an “Internet +” nursing model based on user profiling in the rehabilitation of postoperative breast cancer patients. Methods: Breast cancer patients admitted to the hospital from
Xiuyuan Xie, Yuanfang Ren, Jia Yao, Yujie Fei, Fenghe Liu, Qian Tong, Juanjuan Huang, Meihong Kou, Cuifeng Jin, Weijuan Yang, Haiping Xu   +10 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Psychological burden and resilience factors in patients with Alveolar Echinococcosis - A cross-sectional study.

PLoS Neglected Tropical Diseases, 2019
BackgroundAlveolar echinococcosis (AE) is a parasitic zoonosis resembling malignancy due to its clinically silent infiltrative growth, predominately in the liver.
Christoph Nikendei, Anja Greinacher, Anastasiya Berkunova, Thomas Junghanss, Marija Stojkovic   +4 more
doaj   +1 more source