Results 71 to 80 of about 113,882 (286)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Longitudinal patterns in fear of cancer progression in patients with rare, advanced cancers undergoing comprehensive tumour genomic profiling

Psycho-Oncology, 2021
AbstractIntroductionFear of cancer progression (FCP) impacts quality of life and is a prevalent unmet need in patients diagnosed with advanced cancer, particularly as treatment options are reduced. We aimed to identify longitudinal patterns in FCP over 6 months in patients with advanced cancer receiving comprehensive tumour genomic profiling (CTGP ...
Butow, P, Müller, F, Napier, CE, Bartley, N, Ballinger, ML, Biesecker, B, Juraskova, I, Meiser, B, Schlub, TE, Thomas, DM, Goldstein, D, Best, MC, Newson, A, Tucker, K, Vines, R, Vines, K, Kirk, J, Young, MA, Savard, J, Jacobs, C   +19 more
openaire   +4 more sources

Early nurturing experiences, self-compassion, hyperarousal and scleroderma the way we relate to ourselves may determine disease progression [PDF]

, 2016
<p>Scleroderma is a rare, painful and complex autoimmune connective tissue disease that can lead to death. The physiology of symptom onset and progression and the psychological aspects of living with this chronic disease have been studied fairly ...
Hicks, Richard E., Kearney, Karen
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Illness perceptions, fear of progression and health-related quality of life during acute treatment and follow-up care in paediatric cancer patients and their parents: a cross-sectional study

BMC Psychology, 2023
Background This study examines the role of illness perceptions and fear of progression (FoP) in paediatric cancer patients and their parents for patient’s health-related quality of life (HRQoL), controlling for sociodemographic and medical variables.
Kristina Herzog, Florian Schepper, Thomas Pletschko, Jessy Herrmann, Mihaela Budich, Holger Christiansen, Meinolf Suttorp, Julia Martini   +7 more
doaj   +1 more source

Is ‘Hold Me Tight’ Relationship Enhancement Program Effective in Reducing Fear of Progression in Iranian Married Women with Breast Cancer?

Journal of Muslim Mental Health, 2023
Patients with chronic diseases such as cancer are permanently worried about the progression or recurrence of their diseases. This fear of cancer spreading severely affects a patient’s quality of emotional and marital life.
Ali Zargaran, Masoumeh Hedayati
doaj   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A validity and reliability evaluation of fear of progression questionnaire in Iranian breast cancer patients: A methodological study

Health Science Reports
Background and Aims Recognizing the ability to adapt coping mechanisms in response to the unique issues present in various Iranian societies underscores the importance of considering culture and religion when interacting with diverse groups of ...
Hamid Sharif‐Nia, Pooria Sobhanian, Erika Sivarajan Froelicher, Bahar Farhadi, Sima Hejazi, Amir Hossein Goudarzian, Mobin Mohamadinezhad, Ehsan Zaboli, Mohammad Mohsen Hosseinian, Maryam Hasannezhad Reskati, Seyed Hamzeh Hosseini   +10 more
doaj   +1 more source

Exercise duRing Active Surveillance for prostatE cancer—the ERASE trial: a study protocol of a phase II randomised controlled trial

BMJ Open, 2019
Introduction Active surveillance (AS) is the preferred primary treatment strategy for men with low-risk clinically localised prostate cancer (PCa); however, the majority of these men still receive radical treatment within 10 years due to disease ...
Dong-Woo Kang, Adrian S Fairey, Normand G Boulé, Catherine J Field, Kerry S Courneya   +4 more
doaj   +1 more source