Results 91 to 100 of about 176,150,519 (294)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The impact of cognitive emotion regulation and social alienation chain intermediate role in breast cancer patients experiencing postoperative recurrence of dread for post-traumatic stress disorder

BMC Psychiatry
Objectives This study aims to quantify the extent to which cognitive emotional regulation and social alienation independently and interactively predict the severity of post-traumatic stress disorder symptoms in patients after radical mastectomy for ...
Yanan Zhou, Yani Zhou, Hui Tan
doaj   +1 more source

Screening for fear of cancer recurrence: Instrument validation and current status in early stage lung cancer patients

Journal of the Formosan Medical Association, 2020
Background: Fear of cancer recurrence (FCR) is one of the most distressing concerns for cancer patients. A psychometrically validated brief scale is urgently needed for use in busy clinical oncology settings.
Yun-Hsiang Lee, Chan-Chuan Hu, Gerry Humphris, I-Chin Huang, Kai-Lin You, Sin-Yuan Jhang, Jin-Shing Chen, Yeur-Hur Lai   +7 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Fear of cancer recurrence, anxiety and depressive symptoms in adolescent and young adult cancer patients

, 2019
Hengwen Sun,1,* Yuan Yang,2,3,* Jingying Zhang,3,* Ting Liu,3,* Hongmei Wang,4 Samradhvi Garg,5 Bin Zhang31Department of Radiotherapy, Cancer Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences ...
Yang Y, Zhang J, Garg S, Wang H, Sun H, Liu T, Zhang B   +6 more
core  

Fear of Recurrence in Advanced Cancer Patients: Sociodemographic, Clinical, and Psychological Correlates

Fear of cancer recurrence significantly impacts advanced cancer patients, prompting emotional distress and increased healthcare utilization. This present study aims to analyze the fear of recurrence among patients with advanced cancer undergoing systemic
Maria M. Muñoz-Sánchez, Caterina Calderon, Lorena Ostios-García, Marina Gustems, Paula Jiménez-Fonseca, Rocio Galán-Moral, Calderon, Caterina, Jiménez-Fonseca, Paula, Gustems, Marina, Ostios-García, Lorena, Muñoz-Sánchez, Maria M, Galán-Moral, Rocio   +11 more
core   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the treatment effect of anticoagulation versus antiplatelet therapy in patients ...
Elena Badillo Goicoechea, Patrick Ellsworth, James E. Siegler, James R. Brorson, Christina M. Lineback, Frank G. Conyers, Deborah Kerrigan, Kelsey Eklund, Shadi Yaghi, Farid Khasiyev, Emiliya Melkumova, Collin J. Culbertson, Marissa D'Souza, Dinesh V. Jillella, Patrick Glover, Hassan Aboul‐Nour, Fadi Nahab, Mahan Shahrivari, Simona Nedelcu, David S. Liebeskind, Matthew M. Smith, Aaron Rothstein, Anna Bowman, Alicia Zha, Narendra Kala, Ahmad Abu Qdais, Sami Al Kasab, Mudassir Farooqui, Diana Rojas‐Soto, Yasmin Aziz, Franziska Herpich, Jean‐Philippe Daniel, Sean L. Thompson, Vivek Patel, Thanh N. Nguyen, Siddharth Sehgal, Wenzheng Yu, Wayneho Kam, Russel Van Coevering, Oana M. Dumitrascu, Muhammad Alvi, Balaji Krishnaiah, Setareh Salehi Omran, Guillermo Linares, Eesha Singh, Hamid Ali, Mary Penckofer, Jesse M. Thon, Shani Mannion, Dalia Chahien, Lucia Chen, Fawad Talat, Mehdi Abbasi, Richa Sharma   +53 more
wiley   +1 more source

A qualitative exploration of fear of cancer recurrence in Turkish cancer survivors who were referred for colposcopy

, 2021
We aimed to qualitatively explore factors related to fear of cancer recurrence in women who had a risk of cervical cancer relapse/metastasis and to identify the psychological effect of gynaecological examination and colposcopy in cancer survivors.
Üner, Fatma Özlem, Körükçü, Öznur
core   +1 more source

A photo elicitation study of fear of cancer recurrence and support needs among breast cancer survivors

Scientific Reports
Fear of cancer recurrence (FCR) is one of the most common psychological challenges faced by breast cancer survivors. However, limited qualitative research has examined survivors’ lived experiences, personal interpretations, and support needs related to ...
Weimin Liu, Yali Su, Han You, Huaguo Zhang, Lihui Liu, Ping Lei Chui, Chong Chin Che   +6 more
doaj   +1 more source