Results 61 to 70 of about 167,687,046 (279)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Fear of death: everyday experience-based nurses ’observations in working with elderly and old patients ill with chronic cardiovascular diseases

Taikomieji Moksliniai Tyrimai
Summary Fear of death occurs when elderly and old patients (EOPs) are faced with life-threatening events or extreme psychological stress. For most, anticipation of death triggers negative emotions such as the fear of losing of oneself, helplessness ...
Kristina Bulkina, Vilma Žydžiūnaitė
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cape Fear Ford

Reproduction of a photograph of the Cape Fear Ford dealership near Market Street and Second Street in downtown Wilmington.

core   +3 more sources

Exploring the concept of a “friendly relationship to death” in geriatric patients

BMC Geriatrics
Background Positive attitudes toward death are common among geriatric patients, yet their distinction from mental illness and suicidality remains insufficiently understood.
Zoi Raboti, Alexander Rösler, Reinhard Lindner, Jürgen Gallinat, Brooke C. Schneider   +4 more
doaj   +1 more source

Pеter Lnitskyi as an Apologist Metaphysics in “Age of Science”

Наукові записки НаУКМА: Філософія та релігієзнавство, 2019
The article is about metaphysical studies of Peter Linitskyi’s (1839–1906), a professor of the Department of Logic and Metaphysics in the Kyiv Theological Academy. For many years P. Linitskyi taught students of the Academy all parts of metaphysics.
Viktor Kozlovskyi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Attitudes toward Death among Health Care Professionals in the Balkan Region

Current Oncology
Background and Objectives: Death is an unavoidable experience in any person’s life and affects not only the dying person but also their caregivers. The dying process has been displaced from homes to health care facilities in the majority of cases. Facing
Tomi Kovacevic, Bojan Zaric, Jelena Djekic Malbasa, Darijo Bokan, Borislava Nikolin, Daliborka Bursac, Petar Simurdic, Vladimir Stojsic, Goran Stojanovic, Dragana Maric   +9 more
doaj   +1 more source