Results 91 to 100 of about 381,504 (313)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Both/And: Self-Authoring a Feminist Christian Identity [PDF]
, 2020 This article is my attempt to make sense of the conflicting, confusing, tumultuous journey of making peace with my religion and my commitment to social justice, particularly feminism.
Williams, Molly M.
core +1 more source
Use of the metastatic breast cancer progression (MBC-P) questionnaire to assess the value of progression-free survival for women with metastatic breast cancer. [PDF]
, 2013 While overall survival (OS) has historically been the primary endpoint for clinical trials in oncology, progression-free survival (PFS) has gained acceptance as a valuable surrogate endpoint.
Crosby, Ross D +3 more
core +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Cancer Management and Research, 2020 Zhi-Hui Gu, Tian Qiu, Shi-Han Yang, Fang-Qiong Tian, Hui Wu Department of Social Medicine, School of Public Health, China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Hui WuDepartment of Social Medicine, School of Public ...
Gu ZH, Qiu T, Yang SH, Tian FQ, Wu H
doaj
Place, paradox, and transcendental connection in three of E. M. Forster's novels : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in English at Massey University [PDF]
, 2000 E. M. Forster's fiction reflects his own concern with the spirit of place and his seemingly fruitless search for a spiritual reconciliation between people and places.
Flynn, Alice Catherine
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress [PDF]
Annual Review of Psychology, 2012 The psychology of extinction has been studied for decades. Approximately 10 years ago, however, there began a concerted effort to understand the neural circuits of extinction of fear conditioning, in both animals and humans. Progress during this period has been facilitated by a high degree of coordination between rodent and human researchers examining ...
Mohammed R, Milad, Gregory J, Quirk
openaire +2 more sources
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source