Results 91 to 100 of about 1,528,398 (266)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Including Risk in Economic Feasibility Analyses: The Case of Ethanol Production in Texas

The widespread use of personal computers and spreadsheet models for feasibility studies makes risk-based Monte Carlo simulation analysis of proposed investments a relatively simple task.
Herbst, Brian K., Outlaw, Joe L., Gill, Robert Chope, II, Richardson, James W.   +3 more
core  

Patient and provider preferences for long-acting TB preventive therapy

IJTLD Open
BACKGROUND: Tuberculosis preventive therapy (TPT) is critical for TB elimination but is underutilised. Long-acting (LA) TPT can potentially improve linkage to care, treatment adherence and outcomes.
M. Vermeulen, K.K. Scarsi, R. Furl, H. Sayles, M.J. Anderson, S. Valawalkar, A. Kadam, S.R. Cox, V. Mave, M. Barthwal, C. Schutz, A. Ward, J. Dountio Ofimboudem, G. Meintjes, S. Rannard, A. Owen, S. Swindells, on behalf of the LONGEVITY consortium   +17 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Feasibility of a Co-operative Winery

The number of operating wineries in the United States has doubled during the past decade. Most of this growth has been due to a large number of entrepreneurial landowners developing their own small acreage vineyards and trying to branch into winemaking ...
Kenkel, Philip L., Hill, Amanda, Holcomb, Rodney B.   +2 more
core  

Food for Thought Feasibility Study: Enhancing Food Donations in Cumberland Council Area

, 2023
The aim of this feasibility study is to assess the potential of increasing food donations to the needy in the Cumberland Council community while at the same time reducing the amount of good quality food from going into landfill. Undertaken by a team from
Evangelista , Felicitas U. (R7647), Evangelista , Anna (R20322), Datt, Rina (R18559), Gaffney, Alicia, Varua, Maria (R7195)   +4 more
core  

A virtual reality-based self-guided training on identification of negative automatic thoughts in healthy adults: a mixed-methods feasibility study

Frontiers in Psychiatry
BackgroundCognitive restructuring (CR) is an evidence-based psychological technique for depression. However, face-to-face CR is not easily accessible. Digital CR interventions often overlook the difficulties individuals experiencing depression encounter ...
Bixi Yang, Chenxi Liao, Yuqing Yang, Yuqing Yang, Binbin Shi, Caidi Zhang, Chunbo Li, Chunbo Li, Chunbo Li   +8 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

7.34 S94-027294 Feasibility study

A view of several instruments, noted: Feasibility ...

core  

The Safety, Acceptability, and Feasibility of Single-Dose Rifampicin as Post-Exposure Chemoprophylaxis for Contacts of Leprosy Patients in Togo: A Mixed-Method Sequential Explanatory Study

Tropical Medicine and Infectious Disease
The World Health Organization is encouraging countries to include contact screening and single-dose rifampicin administration as preventive chemotherapy for contacts of leprosy patients in their leprosy control activities.
Akila Wimima Bakoubayi, Falapalaki Haliba, Wendpouiré Ida C. Zida-Compaore, P’tanam P’kontème Bando, Yao Rodion Konu, Abissouwèssim Egbare Tchade, Kodjo Akpadja, Kamevor Alaglo, Maweke Tchalim, P’niwè Patchali, Yaovi Djakpa, Komi Amekuse, Piham Gnossike, Denis A. Yawovi Gadah, Christa Kasang, Didier Koumavi Ekouevi   +15 more
doaj   +1 more source