Results 101 to 110 of about 1,528,398 (266)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

South Valley Incorporation Feasibility Study: Presentation to the South Valley Community

, 2008
Revised "...with minor corrections as noted, October 2008"Slide presentation summarizing the findings of the South Valley incorporation feasibility study.
Reynis, Lee A.
core  

Using Remote Technology to Engage Patients with Interstitial Lung Diseases in a Home Exercise Program: A Pilot Study

Life
Introduction: The access and compliance of patients with interstitial lung diseases (ILDs) to exercise programs (EPs) remain challenges. Objectives: We assessed the dropout rate, intervention completion, compliance with data acquisition and submission ...
Antonio Sarmento, Kaitlin King, Diana C. Sanchez-Ramirez   +2 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Dairy digester feasibility study summary report

, 2010
Anaerobic digestion of dairy manure is a proven technology with a long history, immediately available for commercial applications from a number of qualified vendors.

core  

Intestinal Ultrasonography Diagnostic Performance and Feasibility in IBD during Pregnancy: A Systematic Review and Narrative Synthesis

Inflammatory Intestinal Diseases
Introduction: Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are associated to poor maternal and foetal outcomes during pregnancy, requiring a strict monitoring of the disease activity, preferably with non ...
Julie Pillet, Julia Voirol-Perrin, Myriam Martel, Omar Kherad, Sophie Restellini   +4 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

UPBEAT Trial: a randomised feasibility evaluation of a digital system for UPper limB rEhabilitation After sTroke [PDF]

Background: Stroke rehabilitation is essential, yet many stroke survivors receive insufficient therapy, particularly for arm function. The 2023 UK National Stroke Guidelines recommend ongoing rehabilitation, but resource constraints limit therapy ...
Shi, T, Davies, Jane, Leggat, Fiona, Playle, Rebecca, Ndachi Effiang, Ebenezar, Jones, Fiona, Szymanski, Tomasz, Shepherd, Leila, Goddard, M, Coleman, S, Ndachi Effiang, E, Playle, R, Coleman, Sarah, Darzi, Ara, Ivins, Nicola, Darzi, A, Fusari, G, Davies, J, Richardson, Davina, Richardson, D, Fusari, Gianpaolo, McCrudden, C, McKinlay, R, McKinlay, Richard, Goddard, Mark, Riaz, Muhammad, Lowe, R, Findlay, Joanne, Penny, Louise, Riaz, M, Dearling, J, Lowe, Rachel, Szymanski, T, Dearling, Jeremy, McCrudden, Clare, Jones, F, Penny, L, Findlay, J, Shepherd, L, Ivins, N, Shi, Tongtong, Leggat, F   +41 more
core   +1 more source