Results 101 to 110 of about 4,702,024 (340)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The feasibility of implementing renewable energy systems by local municipalities for households and economic entities

Frontiers in Energy Research
As the urgency to combat climate change, environmental degradation and energy security intensifies, nations globally are exploring sustainable energy alternatives to reduce dependence on fossil fuels.
Olufemi Michael Oladejo, Elvin Shava, Tigere Paidamoyo Muringa   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Feasibility Testing of a Developed Video-Based McKenzie Protocol in the Management of Neck Discomfort [PDF]

Journal of Liaquat National Hospital
Background: Neck pain management has become a burden among patients due to economic hardship, waiting time in the hospital, and inadequate personnel around the nation.
Ogundele Toluwanimi Emmanuel, Adesola Ojo Ojoawo, Taofeek Oluwole Awotidebe   +2 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

On Feasibility and Asymptotically Stability of Switched Systems Using Adaptive Multi-Model Predictive Control

Complex System Modeling and Simulation
The present paper attempts to design an adaptive multi-model predictive control strategy for strongly nonlinear or switched systems with various operating points.
Mohammad Fathi, Hossein Bolandi, Bahman Ghobrani Vaghei, Saeed Ebadollahi   +3 more
doaj   +1 more source

Biodiesel Feasibility Study: An Evaluation of Biodiesel Feasibility in Wisconsin [PDF]

There has been considerable interest focused on the further development and expansion of a domestic bio-fuels industry. While most early attention from the commercial sector focused on ethanol, interest is now growing in the area of biodiesel production.
Fortenbery, T. Randall
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Home spirometry telemonitoring in pediatric patients with asthma: a mixed study

Frontiers in Pediatrics
BackgroundTo evaluate the feasibility and practicality of home spirometry telemonitoring for pediatric patients with asthma, including both motivators and barriers, as well as the requirements for effective implementation.MethodsThis single-arm ...
Dingrong Fan, Ao Shen, Qianqian Wang, Lu Peng, Ruixue Xia, Hengyu Zhou   +5 more
doaj   +1 more source