Results 51 to 60 of about 2,954,255 (299)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Color Transparency at COMPASS - Feasibility Study [PDF]

open access: yes, 2001
We examine the potential of the COMPASS experiment at CERN to study color transparency via exclusive vector meson production in hard muon-nucleus scattering.
Grajek, Oleg A.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Circadian rhythms in the university community: perception of health (dis) synchronisation

open access: yesCogent Education
The aim of this research is to analyze circadian typologies in the community of the University of Burgos (Spain). In this study, 1,067 participants from three groups (students (ST), administrative and service staff (AS) and teaching and research staff ...
María Fernández Hawrylak   +4 more
doaj   +1 more source

The VOICE Study: Valuing Opinions, Individual Communication and Experience: Building the evidence base for undertaking patient-centred family meetings in palliative care - a mixed methods study [PDF]

open access: yes, 2018
Background: Despite family meetings being widely used to facilitate discussion among patients, families, and clinicians in palliative care, there is limited evidence to support their use.
Cahill, Philippa J   +3 more
core   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

TRUTH AND FEASIBLE REDUCIBILITY [PDF]

open access: yesThe Journal of Symbolic Logic, 2019
AbstractLet ${\cal T}$ be any of the three canonical truth theories CT− (compositional truth without extra induction), FS− (Friedman–Sheard truth without extra induction), or KF− (Kripke–Feferman truth without extra induction), where the base theory of ${\cal T}$ is PA (Peano arithmetic). We establish the following theorem, which implies that ${\cal T}$
Enayat, Ali   +2 more
openaire   +3 more sources

A Memristor as Multi-Bit Memory: Feasibility Analysis [PDF]

open access: yes, 2015
The use of emerging memristor materials for advanced electrical devices such as multi-valued logic is expected to outperform today's binary logic digital technologies.
Bass, O., Fish, A., Naveh, D.
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Projection Methods: Swiss Army Knives for Solving Feasibility and Best Approximation Problems with Halfspaces [PDF]

open access: yes, 2013
We model a problem motivated by road design as a feasibility problem. Projections onto the constraint sets are obtained, and projection methods for solving the feasibility problem are studied. We present results of numerical experiments which demonstrate
Bauschke, Heinz H., Koch, Valentin R.
core  

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