Results 61 to 70 of about 1,528,398 (266)
, 2022 BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major reason for consultations in primary care, hospital admissions, deterioration in function, and mortality.
Hu, X-Y +25 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 1977 The President's Committee on Health Sciences Feasibility Studies Vol. 01Membership -- General terms of reference -- Procedures -- Principal recommendations -- Summary of rehabilitation health sciences report.
Health Sciences Education Feasibility Study Committee (N.L.)
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
An Economic model for assessing the feasibility of multilateral wells
, 2001 This paper presents an economic model developed for assessing the feasibility of drilling multilateral wells for exploiting oil reservoirs. Detailed equations are derived for calculating the cost, return on investment and discounted net present value ...
Al-Blehed, M.S. +2 more
core
Education Human and Development Journal, 2018 Tujuan penelitian ini adalah untuk mengembangkan modul IPS berwawasan pendidikan karakter pada materi proklamasi kemerdekaan Indonesia untuk kelas V Sekolah Dasar sehingga diharapkan akan memudahkan guru untuk mengintegrasikan nilai karakter dalam ...
Edy Suratno, Wendri Wiratsiwi
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Economic feasibility of a new method to estimate mortality in crisis-affected and resource-poor settings. [PDF]
, 2011 INTRODUCTION: Mortality data provide essential evidence on the health status of populations in crisis-affected and resource-poor settings and to guide and assess relief operations. Retrospective surveys are commonly used to collect mortality data in such
Francesco Checchi +24 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source