Results 51 to 60 of about 1,635,532 (265)

Transparency of informed consent in pilot and feasibility studies is inadequate: a single-center quality assurance study [PDF]

, 2021
Background Pilot and feasibility studies (PAFS) often have complex objectives aimed at assessing feasibility of conducting a larger study. These may not be clear to participants in pilot studies.
Hopewell, S, Campbell, MJ, Lancaster, G.A., Durrani, Zoha H, Eddy, Saskia, Mellor, Katie, Durrani, Z.H., Holek, Matthew, Durrani, Zoha H., Bdair, F., Thabane, Lehana, Eddy, S, Eldridge, SM, Khan, M.I.U., Bond, Christine, Mellor, K., Eldridge, S.M., Mbuagbaw, L, Hopewell, Sally, Chan, Claire L., Lancaster, Gillian, Eddy, S., Khan, Mohammed IU, Mbuagbaw, Lawrence, Mellor, Katie, Bdair, Faris, Hopewell, S., Thabane, L., Lancaster, GA, Khan, Mohammed Inam, Chan, CL, Eldridge, Sandra, Holek, M., Bdair, F, Bond, Christine M, Holek, M, Eldridge, Sandra M, Bond, C.M., Campbell, M.J., Thabane, L, Chan, Claire L, Bond, CM, Lancaster, Gillian A, Chan, C.L., Khan, MIU, Durrani, ZH, Mbuagbaw, L., Mellor, K, Campbell, Michael J, Khan, Mohammed I   +49 more
core   +1 more source

Circadian rhythms in the university community: perception of health (dis) synchronisation

Cogent Education
The aim of this research is to analyze circadian typologies in the community of the University of Burgos (Spain). In this study, 1,067 participants from three groups (students (ST), administrative and service staff (AS) and teaching and research staff ...
María Fernández Hawrylak, Elena Garrachón-Gómez, Ana García-Rodríguez, Sol García-Rodríguez, Cristina Alonso Tristán   +4 more
doaj   +1 more source

Development of a single market for research services in the Eurasian Economic Union

Ekonomika Nauki, 2019
Based on the analysis of existing regulatory legal acts in the field of regulating the research activities of the member countries of the Eurasian Economic Union (EAEU), a conclusion was made about their similarity and the possibility of starting the ...
V. N. Kuzmin, E. A. Ilyukhina, L. G. Voronetskaya, S. V. Meloyan   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Heterogeneous Extractive Batch Distillation of Chloroform - Methanol – Water : Feasibility and Experiments [PDF]

, 2008
A novel heterogeneous extractive distillation process is considered for separating the azeotropic mixture chloroform – methanol in a batch rectifying column, including for the first time an experimental validation of the process.
Gerbaud, Vincent, Rodríguez-Donis, Ivonne, Van Kaam, Romuald   +2 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Treating Acute EXacerbations of COPD with Chinese HerbAL MedIcine to aid AntiBiotic Use Reduction (EXCALIBUR): study protocol of a randomised double-blind, placebo-controlled feasibility trial

, 2022
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major reason for consultations in primary care, hospital admissions, deterioration in function, and mortality.
Hu, X-Y, Oliver, T, Oliver, Tom, Thomas, Michael, Liu, J-P, Simpson, C, Stuart, Beth, Trill, J, Simpson, Catherine, Little, Paul, Moore, M, Willcox, M, Little, P, Griffiths, G, Hu, Xiao-Yang, Thorne, Kerensa, Moore, Michael, Willcox, Merlin, Francis, Nick, Griffiths, Gareth, Stuart, B, Thorne, K, Thomas, M, Francis, N, Trill, Jeanne, Liu, Jian-Ping   +25 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source