Results 51 to 60 of about 159,781 (259)

Method of Feasible Directions with Hit-and-Run Sampling for Solving Linearly Constrained Multi-Objective Optimization Problems

Journal of Optimization, Differential Equations and Their Applications
This paper proposes an extension of Zoutendijk’s Method of Feasible Directions (MFD) for solving linearly constrained multi-objective optimization problems.
Ramdani Zoubir, Addoune Smail, Brahmi Boualem   +2 more
doaj   +1 more source

Overview of Wind Parameters Sensing Methods and Framework of a Novel MCSPV Recombination Sensing Method for Wind Turbines

Energies, 2018
The paper presents an overview of the traditional methods to obtain wind parameters such as wind speed, wind direction and air density. After analyzing wind turbines’ arrangements and communication characteristics and the correlation of operation ...
Xiaojun Shen, Chongchen Zhou, Guojie Li, Xuejiao Fu, Tek Tjing Lie   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Finite fields and cryptology [PDF]

Computer Science Journal of Moldova, 2003
The problem of a computationally feasible method of finding the discrete logarithm in a (large) finite field is discussed, presenting the main algorithms in this direction.
Ennio Cortellini
doaj  

Deriving solar transient characteristics from single spacecraft STEREO/HI elongation variations: a theoretical assessment of the technique [PDF]

Annales Geophysicae, 2009
Recently, a technique has been developed whereby the radial velocity, Vr, and longitude direction, β, of propagation of an outward-moving solar transient, such as a Coronal Mass Ejection (CME), can be estimated from its track in a time-elongation map ...
A. O. Williams, J. A. Davies, S. E. Milan, A. P. Rouillard, A. P. Rouillard, C. J. Davis, C. H. Perry, R. A. Harrison   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Single-Cell Elasticity Measurement with an Optically Actuated Microrobot

Micromachines, 2020
A cell elasticity measurement method is introduced that uses polymer microtools actuated by holographic optical tweezers. The microtools were prepared with two-photon polymerization. Their shape enables the approach of the cells in any lateral direction.
István Grexa, Tamás Fekete, Judit Molnár, Kinga Molnár, Gaszton Vizsnyiczai, Pál Ormos, Lóránd Kelemen   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source