Results 121 to 130 of about 2,661 (250)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Accuracy of Two Methods in Estimating Target Muscle Force During Shoulder Submaximal Isometric Contractions

International Journal of Sports Physical Therapy
# Background Submaximal isometric exercises are used for pain control and neuromuscular facilitation. Typically, an ipsilateral maximal voluntary isometric contraction (MVIC) is used as a reference; however, when this is not clinically feasible, an ...
Sean F. Griech, Christos Karagiannopoulos   +1 more
doaj   +1 more source

A steepest feasible direction method for linear programming. Derivation and embedding in the simplex method

Operations Research and Decisions
A feasible direction method for linear programming has been proposed. The method is embedded in the framework of the simplex method, even though it works with non-edge feasible directions. The direction used is the steepest in the space of all variables or an approximation thereof, and it is found by solving a strictly convex quadratic program in the ...
Biressaw C. Wolde, Torbjörn Larsson
openaire   +3 more sources

A Switching Criterion in Hybrid Quasi-Newton BFGS - Steepest Descent Direction [PDF]

, 1999
Two modified methods for unconstrained optimization are presented. The methods employ a hybrid descent direction strategy which uses a linear convex combination of quasi-Newton BFGS and steepest descent as search direction.
Abu Hassan, Malik, Monsi, Mansor, Leong, Wah June   +2 more
core  

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Fabrication of Large-Core Multicore Fiber Bragg Gratings Based on Femtosecond Laser Direct Writing Technology

Nanomaterials
We demonstrate the fabrication of the fiber Bragg grating (FBG) in a self-developed Yb-doped seven-core fiber using two femtosecond laser direct writing methods: a grating array inscription method and a plane-by-plane inscription method.
Xinda Lu, Rong Zhao, Chenhui Gao, Xinyu Ye, Qiushi Qin, Hao Li, Zhixian Li, Meng Wang, Zilun Chen, Zefeng Wang   +9 more
doaj   +1 more source

A HETEROGENEOUS ALTERNATING-DIRECTION METHOD FOR A MICRO-MACRO DILUTE POLYMERIC FLUID MODEL

, 2009
We examine a heterogeneous alternating-direction method for the approximate solution of the FENE Fokker-Planck equation from polymer fluid dynamics and we use this method to solve a coupled (macro-micro) Navier-Stokes-Fokker-Planck system for dilute ...
David J. Knezevic, Knezevic, David J., Sueli, E, Knezevic, DJ, Süli, Endre, Endre Süli   +5 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source