Results 101 to 110 of about 2,661 (250)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Investigating the possibility of using different hub height wind turbines in a wind farm

International Journal of Sustainable Energy, 2017
Many researchers have focused on the layout design of a wind farm using the computational methods. Most of previous researches focused on relevant large cell size and using same hub height wind turbines.
Ying Chen, Hua Li, Kai Jin, Yousri Elkassabgi   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Analysis of the Use of Artificial Intelligence in Software-Defined Intelligent Networks: A Survey

Technologies
The distributed structure of traditional networks often fails to promptly and accurately provide the computational power required for artificial intelligence (AI), hindering its practical application and implementation.
Bayron Jesit Ospina Cifuentes, Álvaro Suárez, Vanessa García Pineda, Ricardo Alvarado Jaimes, Alber Oswaldo Montoya Benitez, Juan David Grajales Bustamante   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Mechanical Behavior Analysis of Pipe Roof Using Different Arrangements in Tunnel Construction

Buildings
For tunnels constructed in a single direction, the pipe roof at the tunnel exit portal can be installed either as Outside-to-Inside advanced support arrangements (Out–In ASA) or Inside-to-Outside advanced support arrangements (In–Out ASA). To investigate
Yanbin Luo, Benxian Gao, Jianxun Chen, Chuanwu Wang, Miao Wang, Xiong Qiao   +5 more
doaj   +1 more source

A stochastic approximation counterpart of the feasible direction method

A stochastic approximation counterpart of the feasible direction method of Topkis and Veinott is considered. No convexity condition on a function to be minimized is imposed and a procedure for one-dimensional minimization along each feasible direction ...
Koronacki, Jacek
core  

Steepest descent methods of multicriteria optimization

, 2000
We propose a steepest descent method for unconstrained multicriteria optimization and a "feasible descent direction" method for the constrained case. In the unconstrained case, the objective functions are assumed to be continuously differentiable. In the
Svaiter, Benar Fux, Fliege, Jorg, Svaiter, B   +2 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source