Results 81 to 90 of about 2,661 (250)

Fast Feasible Direction Methods, with Engineering Applications

, 1991
Optimization problems arising in engineering applications often present distinctive features that are not exploited, or not accounted for, in standard numerical optimization algorithms and software codes.
Tits, A.L., Zhou, J.
core  

A generalized super-memory gradient projection method of strongly sub-feasible directions with strong convergence for nonlinear inequality constrained optimization

, 2007
In this work, combining the properties of the generalized super-memory gradient projection methods with the ideas of the strongly sub-feasible directions methods, we present a new algorithm with strong convergence for nonlinear inequality constrained ...
Tang, Chun-Ming, Zeng, You-Fang, Jian, Jin-Bao   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation

BMC Medicine
Background While medications are essential for preventing and treating disease, they can also cause harm. Evidence synthesis has been widely adopted for evaluating harms, but traditional methods are resource-intensive and may constrain timely decision ...
Chang Xu, Suhail A. Doi, Sunita Vohra, Luis Furuya-Kanamori, Yingxia Wang, Lijun Tang, Yuan Tian, Shiqi Fan, Zhen Peng, Evan Mayo-Wilson, Lifeng Lin, Haitao Chu, M. Hassan Murad, Tianqi Yu, Sheyu Li, Yaolong Chen, Su Golder, Yoon Loke, Justin Clark, Paul Glasziou, Liang Du, Houwen Lin, Zhichun Gu, PROMISE Collaborative Research Network   +23 more
doaj   +1 more source

The postural stability of children with foetal alcohol spectrum disorders during one-leg stance: A feasibility study

African Journal of Disability, 2018
Background: Postural control may be impaired in children with foetal alcohol spectrum disorders (FASD). The study assessed the protocol feasibility in terms of (1) recruiting children with FASD in a rural, small town; (2) using the measurement ...
Yolandi Brink, John Cockcroft, Soraya Seedat, Philip May, Wendy Kalberg, Quinette Louw   +5 more
doaj   +1 more source

A combined method for smooth equilibrium problems with nonlinear constraints

, 2020
An iterative method for finding equilibrium points in the case of a smooth convex-concave function and a convex feasible set is proposed. This set is defined by smooth concave functions.
Konnov I.
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Assessment of upright immobilization methods for abdominal and head-and-neck cancer treatments in a carbon ion radiotherapy setting

Technical Innovations & Patient Support in Radiation Oncology
Background and Purpose: Upright patient positioning is an emerging approach in radiotherapy that may overcome current limitations in carbon ion radiotherapy (CIRT).
Maria Varnava, Motohiro Kawashima, Akihiko Matsumura, Yoshiaki Oohashi, Makoto Miyazawa, Junichi Koya, Naoto Yamaguchi, Tomoaki Ogano, Mutsumi Tashiro, Tatsuya Ohno   +9 more
doaj   +1 more source

Identification of direction in gene networks from expression and methylation [PDF]

, 2014
Background: Reverse-engineering gene regulatory networks from expression data is difficult, especially without temporal measurements or interventional experiments. In particular, the causal direction of an edge is generally not statistically identifiable,
Simcha, David M, Younes, Laurent, Aryee, Martin, Geman, Donald   +3 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source