Results 31 to 40 of about 587 (178)

Syntactic and prosodic effects of long-distance wh-movement in Italian [PDF]

, 2018
In this paper we discuss postverbal subjects in Italian direct wh-questions. We show that, in this context, subject inversion is not determined by the information-structural, semantic, or pragmatic conditions that rule ‘free’ subject inversion in ...
BIANCHI, VALENTINA, BOCCI, GIULIANO, Cruschina, Silvio   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Universal Concord as Syntactic Agreement [PDF]

, 2022
This paper argues that universal concord is attested in Cantonese and offers a syntactic agreement account. The Cantonese verbal suffix -can is shown to be a concord element that requires the presence of a universal quantifier but it lacks inherent ...
Yip, Ka-Fai
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Movement from the double object construction is not fully symmetrical [PDF]

, 2019
A movement asymmetry arises in some languages that are otherwise symmetrical for both A- and A-bar movement in the double object construction (DOC), including Norwegian, North-West British English, and a range of Bantu languages including Zulu and ...
Alsina, Alex, Anagnostopoulou, Elena, Anders Holmberg, Assmann, Anke, Baker, Mark C, Beaudoin-Lietz, Christa, Bobaljik, Jonathan David, Bošković, Željko, Bresnan, Joan, Broekhuis, Hans, Chomsky, Noam, Creissels, Denis, Dikken, Marcel den, Duranti, Alessandro, Falk, Cecilia, Haddican, William, Harley, Heidi, Holmberg, Anders, Hornstein, Norbert, Jenneke van der Wal, Jerro, Kyle, Kimenyi, Alexandre, Kitagawa, Yoshihisa, Larson, Richard K, Marantz, Alec, Michelle Sheehan, Morimoto, Yukiko, Morolong, Malillo, Nakamura, Masanori, Ngonyani, Deo, Pesetsky, David, Richards, Norvin, Rizzi, Luigi, Rizzi, Luigi, Schadeberg, Thilo C, Sheehan, Michelle, Sheehan, Michelle, Van der Wal, Jenneke, Van der Wal, Jenneke, Van der Wal, Jenneke, Van Otterloo, Roger, Woolford, Ellen, Zeller, Jochen   +42 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

On non-overt specifiers [PDF]

, 2002
I consider non-overt specifiers, in particular two contexts in which they have been posited. First, SpecIP: in finite clauses in nullsubject languages, SpecIP is standardly assumed to be occupied by a null pronominal (little pro) (Rizzi 1982a).
Rowlett, P
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source