Results 111 to 120 of about 1,444,731 (307)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

FAULT FEATURE EXTRACTION OF HYDRAULIC SYSTEM

open access: yesJixie qiangdu, 2015
Aiming at the problem that the fault feature of hydraulic system is not clear and difficult to diagnosis,a feature extraction method of faults is proposed in this paper which combines EEMD with correlation analysis.
CHEN Hao   +3 more
doaj  

Pcapn: An Enhanced Feature Extraction Framework for Point Cloud

open access: green, 2022
YuLin Ji   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Feature extraction and learning approaches for cancellable biometrics: A survey

open access: yesCAAI Transactions on Intelligence Technology
Biometric recognition is a widely used technology for user authentication. In the application of this technology, biometric security and recognition accuracy are two important issues that should be considered.
Wencheng Yang   +4 more
doaj   +1 more source

Extraction and Analysis of Gully Feature Points Based on DEMs [PDF]

open access: bronze, 2013
Yiqun Xie   +3 more
openalex   +1 more source

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