Results 141 to 150 of about 7,127,658 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Environmental factors contributing to southern house mosquito presence in Clark County, Nevada, using machine learning

Environmental Research Communications
The southern house mosquito ( Culex quinquefasciatus ), a prevalent specie in the southern United States, is a primary vector for diseases including West Nile virus, St. Louis encephalitis, and lymphatic filariasis. In this study, we applied a multi-step
Chibuike Chiedozie Ibebuchi, Itohan-Osa Abu, Somtochukwu Stella Onwah   +2 more
doaj   +1 more source

Intelligent Control Approaches for Warehouse Performance Optimisation in Industry 4.0 Using Machine Learning

Future Internet
In conventional logistics optimization problems, an objective function describes the relationship between parameters. However, in many industrial practices, such a relationship is unknown, and only observational data is available.
Ádám Francuz, Tamás Bányai
doaj   +1 more source

The heatmap of DPC feature importance.

, 2013
The heatmap of DPC feature importance.
Chun-Wei Tung (52367), Chyn Liaw (290346), Shinn-Ying Ho (52368)   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Feature importance score of top 20 SNPs.

, 2019
Feature importance score of top 20 SNPs.
Jae Joseph Russell Rodriguez (8082014), Joverlyn Gaudillo (8082011), Rommel Bulalacao (8082026), Lei Rigi Baltazar (8082020), Julianne Vilela (8082023), Allen Nazareno (8082017), Mario Domingo (8082029), Jason Albia (8082032)   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source