Results 51 to 60 of about 202,798 (258)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IEEE AccessTo solve the problem of insufficient melt pool width feature extraction accuracy caused by splash, arc light, and other interferences in the metal deposition process, a melt pool width extraction method based on the variable step size erosion model is ...
Yuanxin Chai +3 more
doaj +1 more source
Algorithms, 2020 In recent years, a forward-looking subfield of machine learning has emerged with important applications in a variety of scientific fields. Semi-supervised learning is increasingly being recognized as a burgeoning area embracing a plethora of efficient ...
Stamatis Karlos +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Entropy, 2019 This study presents a comprehensive fault diagnosis method for rolling bearings. The method includes two parts: the fault detection and the fault classification.
Weibo Zhang, Jianzhong Zhou
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Frontiers in Plant ScienceIntroductionAccurate mapping of grassland vegetation and bare land is important for grassland degradation assessment and ecological management. This study investigated the effectiveness of integrating visible and multispectral imagery with staged feature
Ying Liu +6 more
doaj +1 more source
Seam Carving as Feature Pooling in CNN
CoRRThis work investigates the potential of seam carving as a feature pooling technique within Convolutional Neural Networks (CNNs) for image classification tasks. We propose replacing the traditional max pooling layer with a seam carving operation. Our experiments on the Caltech-UCSD Birds 200-2011 dataset demonstrate that the seam carving-based CNN ...
openaire +2 more sources