Results 91 to 100 of about 88,907 (241)

Enhancing DDoS Attack Classification through SDN and Machine Learning: A Feature Ranking Analysis

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Due to the growing dependence of digital services on the Internet, Distributed Denial of Service (DDoS) attacks are a common threat that can cause significant disruptions to online operations and financial losses. Machine learning (ML) offers a promising
Aymen AlAwadi, Kawthar Rasoul ALesawi
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Disrupted Brain Network Measures in Parkinson’s Disease Patients with Severe Hyposmia and Cognitively Normal Ability

Brain Sciences
Neuroscience has revolved around brain structural changes, functional activity, and connectivity alteration in Parkinson’s Disease (PD); however, how the network topology organization becomes altered is still unclear, specifically in Parkinson’s patients
Karthik Siva, Palanisamy Ponnusamy, Malmathanraj Ramanathan   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enhancing Supervised Model Performance in Credit Risk Classification Using Sampling Strategies and Feature Ranking

Big Data and Cognitive Computing
For the financial health of lenders and institutions, one important risk assessment called credit risk is about correctly deciding whether or not a borrower will fail to repay a loan.
Niwan Wattanakitrungroj, Pimchanok Wijitkajee, Saichon Jaiyen, Sunisa Sathapornvajana, Sasiporn Tongman   +4 more
doaj   +1 more source

Accurate breast cancer diagnosis using a stable feature ranking algorithm. [PDF]

BMC Med Inform Decis Mak, 2023
Yu S, Jin M, Wen T, Zhao L, Zou X, Liang X, Xie Y, Pan W, Piao C.   +8 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Predicting Cognitive Decline in Motoric Cognitive Risk Syndrome Using Machine Learning Approaches

Diagnostics
Background: Motoric Cognitive Risk Syndrome (MCR), defined by the co-occurrence of subjective cognitive complaints and slow gait, is recognized as a preclinical risk state for cognitive decline.
Jin-Siang Shaw, Ming-Xuan Xu, Fang-Yu Cheng, Pei-Hao Chen   +3 more
doaj   +1 more source

Machine Learning Automatic Model Selection Algorithm for Oceanic Chlorophyll-a Content Retrieval

Remote Sensing, 2018
Ocean Color remote sensing has a great importance in monitoring of aquatic environments. The number of optical imaging sensors onboard satellites has been increasing in the past decades, allowing to retrieve information about various water quality ...
Katalin Blix, Torbjørn Eltoft
doaj   +1 more source